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Alpha 1-Adrenoceptor Blocker May Improve Not Only Voiding But Also Storage Lower Urinary Tract Symptoms Caused by (125)I Brachytherapy for Prostate Cancer

Purpose. To assess changes in lower urinary tract symptoms (LUTS) within 1 year after brachytherapy in patients receiving alpha 1-adrenoceptor antagonists. Methods. We retrospectively evaluated 116 patients who underwent (125)I prostate brachytherapy in our institute. Seventy-one patients were treat...

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Autores principales: Oyama, Nobuyuki, Aoki, Yoshitaka, Ito, Hideaki, Miwa, Yoshiji, Akino, Hironobu, Sato, Yoshitaka, Shioura, Hiroki, Kimura, Hirohiko, Yokoyama, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004040/
https://www.ncbi.nlm.nih.gov/pubmed/25006516
http://dx.doi.org/10.1155/2014/140654
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author Oyama, Nobuyuki
Aoki, Yoshitaka
Ito, Hideaki
Miwa, Yoshiji
Akino, Hironobu
Sato, Yoshitaka
Shioura, Hiroki
Kimura, Hirohiko
Yokoyama, Osamu
author_facet Oyama, Nobuyuki
Aoki, Yoshitaka
Ito, Hideaki
Miwa, Yoshiji
Akino, Hironobu
Sato, Yoshitaka
Shioura, Hiroki
Kimura, Hirohiko
Yokoyama, Osamu
author_sort Oyama, Nobuyuki
collection PubMed
description Purpose. To assess changes in lower urinary tract symptoms (LUTS) within 1 year after brachytherapy in patients receiving alpha 1-adrenoceptor antagonists. Methods. We retrospectively evaluated 116 patients who underwent (125)I prostate brachytherapy in our institute. Seventy-one patients were treated with a combination of external beam radiation therapy and brachytherapy. Alpha 1-adrenoceptor antagonists were prescribed to all patients after brachytherapy. International Prostate Symptom Score (IPSS) forms and postvoid residual urine volume were recorded at all follow-up visits. Results. Forty-nine patients were given tamsulosin hydrochloride, 32 were given silodosin hydrochloride, and 35 were given naftopidil for up to 6 months after seed implantation. Patients given tamsulosin or naftopidil tended to show a higher peak IPSS and slower recovery to baseline values than those given silodosin. The patients given naftopidil showed an insufficient recovery in storage symptoms in naftopidil group in comparison with tamsulosin group at 3 months and with silodosin group at 6 and 9 months. Conclusions. In the management of LUT after brachytherapy, silodosin may provide a more favorable improvement. Silodosin and tamsulosin may have an advantage in improving not only voiding but also storage lower urinary tract symptoms after brachytherapy.
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spelling pubmed-40040402014-07-08 Alpha 1-Adrenoceptor Blocker May Improve Not Only Voiding But Also Storage Lower Urinary Tract Symptoms Caused by (125)I Brachytherapy for Prostate Cancer Oyama, Nobuyuki Aoki, Yoshitaka Ito, Hideaki Miwa, Yoshiji Akino, Hironobu Sato, Yoshitaka Shioura, Hiroki Kimura, Hirohiko Yokoyama, Osamu ISRN Urol Clinical Study Purpose. To assess changes in lower urinary tract symptoms (LUTS) within 1 year after brachytherapy in patients receiving alpha 1-adrenoceptor antagonists. Methods. We retrospectively evaluated 116 patients who underwent (125)I prostate brachytherapy in our institute. Seventy-one patients were treated with a combination of external beam radiation therapy and brachytherapy. Alpha 1-adrenoceptor antagonists were prescribed to all patients after brachytherapy. International Prostate Symptom Score (IPSS) forms and postvoid residual urine volume were recorded at all follow-up visits. Results. Forty-nine patients were given tamsulosin hydrochloride, 32 were given silodosin hydrochloride, and 35 were given naftopidil for up to 6 months after seed implantation. Patients given tamsulosin or naftopidil tended to show a higher peak IPSS and slower recovery to baseline values than those given silodosin. The patients given naftopidil showed an insufficient recovery in storage symptoms in naftopidil group in comparison with tamsulosin group at 3 months and with silodosin group at 6 and 9 months. Conclusions. In the management of LUT after brachytherapy, silodosin may provide a more favorable improvement. Silodosin and tamsulosin may have an advantage in improving not only voiding but also storage lower urinary tract symptoms after brachytherapy. Hindawi Publishing Corporation 2014-03-30 /pmc/articles/PMC4004040/ /pubmed/25006516 http://dx.doi.org/10.1155/2014/140654 Text en Copyright © 2014 Nobuyuki Oyama et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Oyama, Nobuyuki
Aoki, Yoshitaka
Ito, Hideaki
Miwa, Yoshiji
Akino, Hironobu
Sato, Yoshitaka
Shioura, Hiroki
Kimura, Hirohiko
Yokoyama, Osamu
Alpha 1-Adrenoceptor Blocker May Improve Not Only Voiding But Also Storage Lower Urinary Tract Symptoms Caused by (125)I Brachytherapy for Prostate Cancer
title Alpha 1-Adrenoceptor Blocker May Improve Not Only Voiding But Also Storage Lower Urinary Tract Symptoms Caused by (125)I Brachytherapy for Prostate Cancer
title_full Alpha 1-Adrenoceptor Blocker May Improve Not Only Voiding But Also Storage Lower Urinary Tract Symptoms Caused by (125)I Brachytherapy for Prostate Cancer
title_fullStr Alpha 1-Adrenoceptor Blocker May Improve Not Only Voiding But Also Storage Lower Urinary Tract Symptoms Caused by (125)I Brachytherapy for Prostate Cancer
title_full_unstemmed Alpha 1-Adrenoceptor Blocker May Improve Not Only Voiding But Also Storage Lower Urinary Tract Symptoms Caused by (125)I Brachytherapy for Prostate Cancer
title_short Alpha 1-Adrenoceptor Blocker May Improve Not Only Voiding But Also Storage Lower Urinary Tract Symptoms Caused by (125)I Brachytherapy for Prostate Cancer
title_sort alpha 1-adrenoceptor blocker may improve not only voiding but also storage lower urinary tract symptoms caused by (125)i brachytherapy for prostate cancer
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004040/
https://www.ncbi.nlm.nih.gov/pubmed/25006516
http://dx.doi.org/10.1155/2014/140654
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