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Absence of Correlation between IL-28B Gene Polymorphisms and the Clinical Presentation of Chronic Hepatitis B in an Amazon Brazilian Population
Objective. The present study investigated the prevalence of the IL-28B polymorphisms rs12979860 and rs8099917 in chronic hepatitis B patients from a case study in Eastern Amazonia. Methods. In total, 65 chronically infected HBV patients and 97 healthy subjects who were anti-HBc and anti-HBs positive...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004099/ https://www.ncbi.nlm.nih.gov/pubmed/24817780 http://dx.doi.org/10.1155/2014/534534 |
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author | da Silva Conde, Simone Regina Souza Rocha, Luciana L. Ferreira, Vanessa M. Soares Monteiro, Julius Caesar Mendes Fonseca Filgueiras, Nathália Karla de Almeida Lins, Pedro Alves Silva dos Santos, Bruna Tereza Bonfim Freitas, Felipe da Silva Graça, Ednelza Demachki, Sâmia Ferreira de Araújo, Marialva Tereza Ishak, Ricardo Vallinoto, Antonio C. R. |
author_facet | da Silva Conde, Simone Regina Souza Rocha, Luciana L. Ferreira, Vanessa M. Soares Monteiro, Julius Caesar Mendes Fonseca Filgueiras, Nathália Karla de Almeida Lins, Pedro Alves Silva dos Santos, Bruna Tereza Bonfim Freitas, Felipe da Silva Graça, Ednelza Demachki, Sâmia Ferreira de Araújo, Marialva Tereza Ishak, Ricardo Vallinoto, Antonio C. R. |
author_sort | da Silva Conde, Simone Regina Souza |
collection | PubMed |
description | Objective. The present study investigated the prevalence of the IL-28B polymorphisms rs12979860 and rs8099917 in chronic hepatitis B patients from a case study in Eastern Amazonia. Methods. In total, 65 chronically infected HBV patients and 97 healthy subjects who were anti-HBc and anti-HBs positive (control group) were evaluated between May 2011 and December 2012. The groups of patients were designated as inactive carriers, chronic hepatitis without cirrhosis, and chronic hepatitis with cirrhosis based on clinical, pathological, biochemical, hematological, and virological variables. The patients were genotyped using quantitative real-time PCR. Results. The frequencies of the rs12979860 polymorphism were similar between the infected group (32.3% CC, 41.5% CT, and 26.2 TT) and the control population (35% CC, 47.4% CT, and 17.6% TT), and the frequencies of the rs8099917 polymorphism (7.7% GG, 35.4% GT, and 56.9% TT versus 7.2% GG, 35.1% GT, and 57.7% TT) were also similar in both groups. The associations between the rs12979860 and rs8099917 polymorphisms and the clinical manifestations were not statistically significant. Conclusion. In conclusion, these polymorphisms had a similar distribution between infected and control groups, indicating that they were not associated with susceptibility and the clinical evolution of hepatitis B in the examined population. |
format | Online Article Text |
id | pubmed-4004099 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40040992014-05-11 Absence of Correlation between IL-28B Gene Polymorphisms and the Clinical Presentation of Chronic Hepatitis B in an Amazon Brazilian Population da Silva Conde, Simone Regina Souza Rocha, Luciana L. Ferreira, Vanessa M. Soares Monteiro, Julius Caesar Mendes Fonseca Filgueiras, Nathália Karla de Almeida Lins, Pedro Alves Silva dos Santos, Bruna Tereza Bonfim Freitas, Felipe da Silva Graça, Ednelza Demachki, Sâmia Ferreira de Araújo, Marialva Tereza Ishak, Ricardo Vallinoto, Antonio C. R. Dis Markers Research Article Objective. The present study investigated the prevalence of the IL-28B polymorphisms rs12979860 and rs8099917 in chronic hepatitis B patients from a case study in Eastern Amazonia. Methods. In total, 65 chronically infected HBV patients and 97 healthy subjects who were anti-HBc and anti-HBs positive (control group) were evaluated between May 2011 and December 2012. The groups of patients were designated as inactive carriers, chronic hepatitis without cirrhosis, and chronic hepatitis with cirrhosis based on clinical, pathological, biochemical, hematological, and virological variables. The patients were genotyped using quantitative real-time PCR. Results. The frequencies of the rs12979860 polymorphism were similar between the infected group (32.3% CC, 41.5% CT, and 26.2 TT) and the control population (35% CC, 47.4% CT, and 17.6% TT), and the frequencies of the rs8099917 polymorphism (7.7% GG, 35.4% GT, and 56.9% TT versus 7.2% GG, 35.1% GT, and 57.7% TT) were also similar in both groups. The associations between the rs12979860 and rs8099917 polymorphisms and the clinical manifestations were not statistically significant. Conclusion. In conclusion, these polymorphisms had a similar distribution between infected and control groups, indicating that they were not associated with susceptibility and the clinical evolution of hepatitis B in the examined population. Hindawi Publishing Corporation 2014 2014-04-10 /pmc/articles/PMC4004099/ /pubmed/24817780 http://dx.doi.org/10.1155/2014/534534 Text en Copyright © 2014 Simone Regina Souza da Silva Conde et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article da Silva Conde, Simone Regina Souza Rocha, Luciana L. Ferreira, Vanessa M. Soares Monteiro, Julius Caesar Mendes Fonseca Filgueiras, Nathália Karla de Almeida Lins, Pedro Alves Silva dos Santos, Bruna Tereza Bonfim Freitas, Felipe da Silva Graça, Ednelza Demachki, Sâmia Ferreira de Araújo, Marialva Tereza Ishak, Ricardo Vallinoto, Antonio C. R. Absence of Correlation between IL-28B Gene Polymorphisms and the Clinical Presentation of Chronic Hepatitis B in an Amazon Brazilian Population |
title | Absence of Correlation between IL-28B Gene Polymorphisms and the Clinical Presentation of Chronic Hepatitis B in an Amazon Brazilian Population |
title_full | Absence of Correlation between IL-28B Gene Polymorphisms and the Clinical Presentation of Chronic Hepatitis B in an Amazon Brazilian Population |
title_fullStr | Absence of Correlation between IL-28B Gene Polymorphisms and the Clinical Presentation of Chronic Hepatitis B in an Amazon Brazilian Population |
title_full_unstemmed | Absence of Correlation between IL-28B Gene Polymorphisms and the Clinical Presentation of Chronic Hepatitis B in an Amazon Brazilian Population |
title_short | Absence of Correlation between IL-28B Gene Polymorphisms and the Clinical Presentation of Chronic Hepatitis B in an Amazon Brazilian Population |
title_sort | absence of correlation between il-28b gene polymorphisms and the clinical presentation of chronic hepatitis b in an amazon brazilian population |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004099/ https://www.ncbi.nlm.nih.gov/pubmed/24817780 http://dx.doi.org/10.1155/2014/534534 |
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