Does protein kinase R mediate TNF-α- and ceramide-induced increases in expression and activation of matrix metalloproteinases in articular cartilage by a novel mechanism?

We investigated the role of the proinflammatory cytokine TNF-α, the second messenger C(2)-ceramide, and protein kinase R (PKR) in bovine articular cartilage degradation. Bovine articular cartilage explants were stimulated with C(2)-ceramide or TNF-α for 24 hours. To inhibit the activation of PKR, 2-...

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Detalles Bibliográficos
Autores principales: Gilbert, Sophie J, Duance, Victor C, Mason, Deborah J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC400415/
https://www.ncbi.nlm.nih.gov/pubmed/14979937
http://dx.doi.org/10.1186/ar1024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC400415/
https://www.ncbi.nlm.nih.gov/pubmed/14979937
http://dx.doi.org/10.1186/ar1024

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