Cargando…
Does protein kinase R mediate TNF-α- and ceramide-induced increases in expression and activation of matrix metalloproteinases in articular cartilage by a novel mechanism?
We investigated the role of the proinflammatory cytokine TNF-α, the second messenger C(2)-ceramide, and protein kinase R (PKR) in bovine articular cartilage degradation. Bovine articular cartilage explants were stimulated with C(2)-ceramide or TNF-α for 24 hours. To inhibit the activation of PKR, 2-...
| Autores principales: | , , |
|---|---|
| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2004
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC400415/ https://www.ncbi.nlm.nih.gov/pubmed/14979937 http://dx.doi.org/10.1186/ar1024 |