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Restriction of the Conformational Dynamics of the Cyclic Acyldepsipeptide Antibiotics Improves Their Antibacterial Activity

[Image: see text] The cyclic acyldepsipeptide (ADEP) antibiotics are a new class of antibacterial agents that kill bacteria via a mechanism that is distinct from all clinically used drugs. These molecules bind and dysregulate the activity of the ClpP peptidase. The potential of these antibiotics as...

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Detalles Bibliográficos
Autores principales:	Carney, Daniel W., Schmitz, Karl R., Truong, Jonathan V., Sauer, Robert T., Sello, Jason K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004210/ https://www.ncbi.nlm.nih.gov/pubmed/24422534 http://dx.doi.org/10.1021/ja410385c

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