Suppressive Effects of D-Glucosamine on the 5-HT Sensitive Nociceptive Units in the Rat Tooth Pulpal Nerve

It is well known that D-glucosamine hydrochloride (DGL) has a variety of biological activities and is regarded as a nutritional supplement effective in improving various disorders, including osteoarthritis and atherosclerosis. Although it has been reported that DGL has a significant pain relief effe...

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Detalles Bibliográficos
Autores principales: Kaida, Kei, Yamashita, Hiromi, Toda, Kazuo, Hayashi, Yoshihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004231/
https://www.ncbi.nlm.nih.gov/pubmed/24818130
http://dx.doi.org/10.1155/2014/187989
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author Kaida, Kei
Yamashita, Hiromi
Toda, Kazuo
Hayashi, Yoshihiko
author_facet Kaida, Kei
Yamashita, Hiromi
Toda, Kazuo
Hayashi, Yoshihiko
author_sort Kaida, Kei
collection PubMed
description It is well known that D-glucosamine hydrochloride (DGL) has a variety of biological activities and is regarded as a nutritional supplement effective in improving various disorders, including osteoarthritis and atherosclerosis. Although it has been reported that DGL has a significant pain relief effect in treating osteoarthritis, little is known about the characteristics of the effects of this compound on dental pain. The present study was undertaken to evaluate the applicability of DGL as a medicament to control pulpalgia. Using an in vitro rat mandible-inferior alveolar nerve preparation (jaw-nerve preparation), we evaluated the effects of DGL on 5-hydroxytryptamine (5-HT) sensitive nociceptive responses in the tooth pulpal nerve. 5-HT-induced nociceptive responses were fairly suppressed by direct application of DGL, suggesting that DGL have a pain relief effect on patients with dental pain.
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spelling pubmed-40042312014-05-11 Suppressive Effects of D-Glucosamine on the 5-HT Sensitive Nociceptive Units in the Rat Tooth Pulpal Nerve Kaida, Kei Yamashita, Hiromi Toda, Kazuo Hayashi, Yoshihiko Biomed Res Int Research Article It is well known that D-glucosamine hydrochloride (DGL) has a variety of biological activities and is regarded as a nutritional supplement effective in improving various disorders, including osteoarthritis and atherosclerosis. Although it has been reported that DGL has a significant pain relief effect in treating osteoarthritis, little is known about the characteristics of the effects of this compound on dental pain. The present study was undertaken to evaluate the applicability of DGL as a medicament to control pulpalgia. Using an in vitro rat mandible-inferior alveolar nerve preparation (jaw-nerve preparation), we evaluated the effects of DGL on 5-hydroxytryptamine (5-HT) sensitive nociceptive responses in the tooth pulpal nerve. 5-HT-induced nociceptive responses were fairly suppressed by direct application of DGL, suggesting that DGL have a pain relief effect on patients with dental pain. Hindawi Publishing Corporation 2014 2014-04-13 /pmc/articles/PMC4004231/ /pubmed/24818130 http://dx.doi.org/10.1155/2014/187989 Text en Copyright © 2014 Kei Kaida et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kaida, Kei
Yamashita, Hiromi
Toda, Kazuo
Hayashi, Yoshihiko
Suppressive Effects of D-Glucosamine on the 5-HT Sensitive Nociceptive Units in the Rat Tooth Pulpal Nerve
title Suppressive Effects of D-Glucosamine on the 5-HT Sensitive Nociceptive Units in the Rat Tooth Pulpal Nerve
title_full Suppressive Effects of D-Glucosamine on the 5-HT Sensitive Nociceptive Units in the Rat Tooth Pulpal Nerve
title_fullStr Suppressive Effects of D-Glucosamine on the 5-HT Sensitive Nociceptive Units in the Rat Tooth Pulpal Nerve
title_full_unstemmed Suppressive Effects of D-Glucosamine on the 5-HT Sensitive Nociceptive Units in the Rat Tooth Pulpal Nerve
title_short Suppressive Effects of D-Glucosamine on the 5-HT Sensitive Nociceptive Units in the Rat Tooth Pulpal Nerve
title_sort suppressive effects of d-glucosamine on the 5-ht sensitive nociceptive units in the rat tooth pulpal nerve
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004231/
https://www.ncbi.nlm.nih.gov/pubmed/24818130
http://dx.doi.org/10.1155/2014/187989
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