Non-native Soluble Oligomers of Cu/Zn Superoxide Dismutase (SOD1) Contain a Conformational Epitope Linked to Cytotoxicity in Amyotrophic Lateral Sclerosis (ALS)

[Image: see text] Soluble misfolded Cu/Zn superoxide dismutase (SOD1) is implicated in motor neuron death in amyotrophic lateral sclerosis (ALS); however, the relative toxicities of the various non-native species formed by SOD1 as it misfolds and aggregates are unknown. Here, we demonstrate that ear...

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Detalles Bibliográficos
Autores principales: Redler, Rachel L., Fee, Lanette, Fay, James M., Caplow, Michael, Dokholyan, Nikolay V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004233/
https://www.ncbi.nlm.nih.gov/pubmed/24660965
http://dx.doi.org/10.1021/bi500158w

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