Cargando…
Rare Individual Amyloid-β Oligomers Act on Astrocytes to Initiate Neuronal Damage
[Image: see text] Oligomers of the amyloid-β (Aβ) peptide have been implicated in the neurotoxicity associated with Alzheimer’s disease. We have used single-molecule techniques to examine quantitatively the cellular effects of adding well characterized Aβ oligomers to primary hippocampal cells and h...
Autores principales: | Narayan, Priyanka, Holmström, Kira M., Kim, Dong-Hyun, Whitcomb, Daniel J., Wilson, Mark R., St. George-Hyslop, Peter, Wood, Nicholas W., Dobson, Christopher M., Cho, Kwangwook, Abramov, Andrey Y., Klenerman, David |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American
Chemical Society
2014
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004235/ https://www.ncbi.nlm.nih.gov/pubmed/24717093 http://dx.doi.org/10.1021/bi401606f |
Ejemplares similares
-
Single-Molecule Imaging Reveals that Small Amyloid-β(1–42) Oligomers Interact with the Cellular Prion Protein (PrP(C))
por: Ganzinger, Kristina A, et al.
Publicado: (2014) -
Intracellular oligomeric amyloid-beta rapidly regulates GluA1 subunit of AMPA receptor in the hippocampus
por: Whitcomb, Daniel J., et al.
Publicado: (2015) -
Quantitative analysis of co-oligomer formation by amyloid-beta peptide isoforms
por: Iljina, Marija, et al.
Publicado: (2016) -
Single Molecule Characterization
of the Interactions
between Amyloid-β Peptides and the Membranes of Hippocampal
Cells
por: Narayan, Priyanka, et al.
Publicado: (2013) -
Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat neuronal cell death
por: Hughes, Craig, et al.
Publicado: (2020)