Decarboxylative Arylation of α-Amino Acids via Photoredox Catalysis: A One-Step Conversion of Biomass to Drug Pharmacophore

[Image: see text] The direct decarboxylative arylation of α-amino acids has been achieved via visible light-mediated photoredox catalysis. This method offers rapid entry to prevalent benzylic amine architectures from an abundant biomass, specifically α-amino acid precursors. Significant substrate sc...

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Detalles Bibliográficos
Autores principales: Zuo, Zhiwei, MacMillan, David W. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004246/
https://www.ncbi.nlm.nih.gov/pubmed/24712922
http://dx.doi.org/10.1021/ja501621q
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author Zuo, Zhiwei
MacMillan, David W. C.
author_facet Zuo, Zhiwei
MacMillan, David W. C.
author_sort Zuo, Zhiwei
collection PubMed
description [Image: see text] The direct decarboxylative arylation of α-amino acids has been achieved via visible light-mediated photoredox catalysis. This method offers rapid entry to prevalent benzylic amine architectures from an abundant biomass, specifically α-amino acid precursors. Significant substrate scope is observed with respect to both the amino acid and arene components.
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spelling pubmed-40042462015-03-12 Decarboxylative Arylation of α-Amino Acids via Photoredox Catalysis: A One-Step Conversion of Biomass to Drug Pharmacophore Zuo, Zhiwei MacMillan, David W. C. J Am Chem Soc [Image: see text] The direct decarboxylative arylation of α-amino acids has been achieved via visible light-mediated photoredox catalysis. This method offers rapid entry to prevalent benzylic amine architectures from an abundant biomass, specifically α-amino acid precursors. Significant substrate scope is observed with respect to both the amino acid and arene components. American Chemical Society 2014-03-12 2014-04-09 /pmc/articles/PMC4004246/ /pubmed/24712922 http://dx.doi.org/10.1021/ja501621q Text en Copyright © 2014 American Chemical Society
spellingShingle Zuo, Zhiwei
MacMillan, David W. C.
Decarboxylative Arylation of α-Amino Acids via Photoredox Catalysis: A One-Step Conversion of Biomass to Drug Pharmacophore
title Decarboxylative Arylation of α-Amino Acids via Photoredox Catalysis: A One-Step Conversion of Biomass to Drug Pharmacophore
title_full Decarboxylative Arylation of α-Amino Acids via Photoredox Catalysis: A One-Step Conversion of Biomass to Drug Pharmacophore
title_fullStr Decarboxylative Arylation of α-Amino Acids via Photoredox Catalysis: A One-Step Conversion of Biomass to Drug Pharmacophore
title_full_unstemmed Decarboxylative Arylation of α-Amino Acids via Photoredox Catalysis: A One-Step Conversion of Biomass to Drug Pharmacophore
title_short Decarboxylative Arylation of α-Amino Acids via Photoredox Catalysis: A One-Step Conversion of Biomass to Drug Pharmacophore
title_sort decarboxylative arylation of α-amino acids via photoredox catalysis: a one-step conversion of biomass to drug pharmacophore
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004246/
https://www.ncbi.nlm.nih.gov/pubmed/24712922
http://dx.doi.org/10.1021/ja501621q
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