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OGlcNAcylation and Phosphorylation Have Opposing Structural Effects in tau: Phosphothreonine Induces Particular Conformational Order

[Image: see text] Phosphorylation and OGlcNAcylation are dynamic intracellular protein post-translational modifications that frequently are alternatively observed on the same serine and threonine residues. Phosphorylation and OGlcNAcylation commonly occur in natively disordered regions of proteins,...

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Detalles Bibliográficos
Autores principales: Brister, Michael A., Pandey, Anil K., Bielska, Agata A., Zondlo, Neal J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004249/
https://www.ncbi.nlm.nih.gov/pubmed/24559475
http://dx.doi.org/10.1021/ja407156m