A Structural and Energetic Model for the Slow-Onset Inhibition of the Mycobacterium tuberculosis Enoyl-ACP Reductase InhA

[Image: see text] Slow-onset enzyme inhibitors are of great interest for drug discovery programs since the slow dissociation of the inhibitor from the drug–target complex results in sustained target occupancy leading to improved pharmacodynamics. However, the structural basis for slow-onset inhibiti...

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Detalles Bibliográficos
Autores principales: Li, Huei-Jiun, Lai, Cheng-Tsung, Pan, Pan, Yu, Weixuan, Liu, Nina, Bommineni, Gopal R., Garcia-Diaz, Miguel, Simmerling, Carlos, Tonge, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004265/
https://www.ncbi.nlm.nih.gov/pubmed/24527857
http://dx.doi.org/10.1021/cb400896g

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