Oxacycle Synthesis via Intramolecular Reaction of Carbanions and Peroxides

[Image: see text] The intramolecular reaction of dialkyl peroxides with carbanions, generated via chemoselective metal-heteroatom exchange or deprotonation, provides a new approach to cyclic ethers. Applied in tandem with C–C bond formation, the strategy enables a one-step annelation to form oxaospi...

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Autores principales: Willand-Charnley, Rachel, Puffer, Benjamin W., Dussault, Patrick H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004269/
https://www.ncbi.nlm.nih.gov/pubmed/24702123
http://dx.doi.org/10.1021/ja5026276
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author Willand-Charnley, Rachel
Puffer, Benjamin W.
Dussault, Patrick H.
author_facet Willand-Charnley, Rachel
Puffer, Benjamin W.
Dussault, Patrick H.
author_sort Willand-Charnley, Rachel
collection PubMed
description [Image: see text] The intramolecular reaction of dialkyl peroxides with carbanions, generated via chemoselective metal-heteroatom exchange or deprotonation, provides a new approach to cyclic ethers. Applied in tandem with C–C bond formation, the strategy enables a one-step annelation to form oxaospirocycles.
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spelling pubmed-40042692015-04-04 Oxacycle Synthesis via Intramolecular Reaction of Carbanions and Peroxides Willand-Charnley, Rachel Puffer, Benjamin W. Dussault, Patrick H. J Am Chem Soc [Image: see text] The intramolecular reaction of dialkyl peroxides with carbanions, generated via chemoselective metal-heteroatom exchange or deprotonation, provides a new approach to cyclic ethers. Applied in tandem with C–C bond formation, the strategy enables a one-step annelation to form oxaospirocycles. American Chemical Society 2014-04-04 2014-04-23 /pmc/articles/PMC4004269/ /pubmed/24702123 http://dx.doi.org/10.1021/ja5026276 Text en Copyright © 2014 American Chemical Society
spellingShingle Willand-Charnley, Rachel
Puffer, Benjamin W.
Dussault, Patrick H.
Oxacycle Synthesis via Intramolecular Reaction of Carbanions and Peroxides
title Oxacycle Synthesis via Intramolecular Reaction of Carbanions and Peroxides
title_full Oxacycle Synthesis via Intramolecular Reaction of Carbanions and Peroxides
title_fullStr Oxacycle Synthesis via Intramolecular Reaction of Carbanions and Peroxides
title_full_unstemmed Oxacycle Synthesis via Intramolecular Reaction of Carbanions and Peroxides
title_short Oxacycle Synthesis via Intramolecular Reaction of Carbanions and Peroxides
title_sort oxacycle synthesis via intramolecular reaction of carbanions and peroxides
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004269/
https://www.ncbi.nlm.nih.gov/pubmed/24702123
http://dx.doi.org/10.1021/ja5026276
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AT dussaultpatrickh oxacyclesynthesisviaintramolecularreactionofcarbanionsandperoxides

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