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Anti-Sa antibodies: prognostic and pathogenetic significance to rheumatoid arthritis
Anti-Sa antibodies are detected in the serum of 20–47% of patients with rheumatoid arthritis. These antibodies have a high degree of specificity for the disease, and appear to identify a subset of early rheumatoid arthritis patients destined to have aggressive and destructive disease. It has recentl...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2004
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC400444/ https://www.ncbi.nlm.nih.gov/pubmed/15059270 http://dx.doi.org/10.1186/ar1171 |
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author | El-Gabalawy, Hani S Wilkins, John A |
author_facet | El-Gabalawy, Hani S Wilkins, John A |
author_sort | El-Gabalawy, Hani S |
collection | PubMed |
description | Anti-Sa antibodies are detected in the serum of 20–47% of patients with rheumatoid arthritis. These antibodies have a high degree of specificity for the disease, and appear to identify a subset of early rheumatoid arthritis patients destined to have aggressive and destructive disease. It has recently been confirmed that anti-Sa antibodies are directed to citrullinated vimentin, thus placing them in the anti-citrulline family of autoantibodies. The Sa antigen has previously been shown to be present in synovium. This, along with the demonstration of citrullinated proteins in rheumatoid synovium, suggests that anti-Sa antibodies may play a pathogenetic role in the initiation and/or persistence of rheumatoid synovitis. |
format | Text |
id | pubmed-400444 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2004 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-4004442004-04-30 Anti-Sa antibodies: prognostic and pathogenetic significance to rheumatoid arthritis El-Gabalawy, Hani S Wilkins, John A Arthritis Res Ther Commentary Anti-Sa antibodies are detected in the serum of 20–47% of patients with rheumatoid arthritis. These antibodies have a high degree of specificity for the disease, and appear to identify a subset of early rheumatoid arthritis patients destined to have aggressive and destructive disease. It has recently been confirmed that anti-Sa antibodies are directed to citrullinated vimentin, thus placing them in the anti-citrulline family of autoantibodies. The Sa antigen has previously been shown to be present in synovium. This, along with the demonstration of citrullinated proteins in rheumatoid synovium, suggests that anti-Sa antibodies may play a pathogenetic role in the initiation and/or persistence of rheumatoid synovitis. BioMed Central 2004 2004-03-10 /pmc/articles/PMC400444/ /pubmed/15059270 http://dx.doi.org/10.1186/ar1171 Text en Copyright © 2004 BioMed Central Ltd |
spellingShingle | Commentary El-Gabalawy, Hani S Wilkins, John A Anti-Sa antibodies: prognostic and pathogenetic significance to rheumatoid arthritis |
title | Anti-Sa antibodies: prognostic and pathogenetic significance to rheumatoid arthritis |
title_full | Anti-Sa antibodies: prognostic and pathogenetic significance to rheumatoid arthritis |
title_fullStr | Anti-Sa antibodies: prognostic and pathogenetic significance to rheumatoid arthritis |
title_full_unstemmed | Anti-Sa antibodies: prognostic and pathogenetic significance to rheumatoid arthritis |
title_short | Anti-Sa antibodies: prognostic and pathogenetic significance to rheumatoid arthritis |
title_sort | anti-sa antibodies: prognostic and pathogenetic significance to rheumatoid arthritis |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC400444/ https://www.ncbi.nlm.nih.gov/pubmed/15059270 http://dx.doi.org/10.1186/ar1171 |
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