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The effect of erythropoietin to pulmonary injury and mast cells secondary to acute pancreatitis

BACKGROUND: Acute pancreatitis is a life-threatening necroinflammatory disease that is characterized by systemic inflammatory response syndrome and acute lung injury even in its very first days. Erythropoietin (EPO) is a hormone considered as an antiapoptotic and cytoprotective with observed recepto...

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Autores principales: Korkmaz, Tanzer, Kahramansoy, Nurettin, Kilicgun, Ali, Firat, Tulin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004514/
https://www.ncbi.nlm.nih.gov/pubmed/24761770
http://dx.doi.org/10.1186/1756-0500-7-267
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author Korkmaz, Tanzer
Kahramansoy, Nurettin
Kilicgun, Ali
Firat, Tulin
author_facet Korkmaz, Tanzer
Kahramansoy, Nurettin
Kilicgun, Ali
Firat, Tulin
author_sort Korkmaz, Tanzer
collection PubMed
description BACKGROUND: Acute pancreatitis is a life-threatening necroinflammatory disease that is characterized by systemic inflammatory response syndrome and acute lung injury even in its very first days. Erythropoietin (EPO) is a hormone considered as an antiapoptotic and cytoprotective with observed receptors of anti-inflammatory effect on organs apart from the liver and the kidneys. In this study, the effects of EPO on pulmonary mast cells and on secondary injury caused by acute pancreatitis are investigated. METHODS: Twenty one Wistar Albino rats were divided into three groups—sham, control, and EPO groups—with 7 rats per group. Pancreatitis was induced by administering 4.5% sodium taurocholate into the pancreatic duct. A 1000 U/kg/day dosage (three times) of EPO was administered to the EPO group. Blood urea nitrogen (BUN), creatinine, amylase, and troponin I in the serum were studied; and lung, kidney, brain, and heart tissues were examined histopathologically. RESULTS: There were no histopathological changes in the other organ tissues except for the lung tissue. Compared to the control group, the EPO group showed significantly reduced alveolar hemorrhage, septal neutrophil infiltration, lung wall thickness score, and mast cell count in the lung tissue. CONCLUSIONS: Administration of EPO reduces the mast cell count and lung wall thickness, and it reduces the alveolar hemorrhage and septal infiltration induced by acute pancreatitis.
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spelling pubmed-40045142014-04-30 The effect of erythropoietin to pulmonary injury and mast cells secondary to acute pancreatitis Korkmaz, Tanzer Kahramansoy, Nurettin Kilicgun, Ali Firat, Tulin BMC Res Notes Research Article BACKGROUND: Acute pancreatitis is a life-threatening necroinflammatory disease that is characterized by systemic inflammatory response syndrome and acute lung injury even in its very first days. Erythropoietin (EPO) is a hormone considered as an antiapoptotic and cytoprotective with observed receptors of anti-inflammatory effect on organs apart from the liver and the kidneys. In this study, the effects of EPO on pulmonary mast cells and on secondary injury caused by acute pancreatitis are investigated. METHODS: Twenty one Wistar Albino rats were divided into three groups—sham, control, and EPO groups—with 7 rats per group. Pancreatitis was induced by administering 4.5% sodium taurocholate into the pancreatic duct. A 1000 U/kg/day dosage (three times) of EPO was administered to the EPO group. Blood urea nitrogen (BUN), creatinine, amylase, and troponin I in the serum were studied; and lung, kidney, brain, and heart tissues were examined histopathologically. RESULTS: There were no histopathological changes in the other organ tissues except for the lung tissue. Compared to the control group, the EPO group showed significantly reduced alveolar hemorrhage, septal neutrophil infiltration, lung wall thickness score, and mast cell count in the lung tissue. CONCLUSIONS: Administration of EPO reduces the mast cell count and lung wall thickness, and it reduces the alveolar hemorrhage and septal infiltration induced by acute pancreatitis. BioMed Central 2014-04-24 /pmc/articles/PMC4004514/ /pubmed/24761770 http://dx.doi.org/10.1186/1756-0500-7-267 Text en Copyright © 2014 Korkmaz et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Research Article
Korkmaz, Tanzer
Kahramansoy, Nurettin
Kilicgun, Ali
Firat, Tulin
The effect of erythropoietin to pulmonary injury and mast cells secondary to acute pancreatitis
title The effect of erythropoietin to pulmonary injury and mast cells secondary to acute pancreatitis
title_full The effect of erythropoietin to pulmonary injury and mast cells secondary to acute pancreatitis
title_fullStr The effect of erythropoietin to pulmonary injury and mast cells secondary to acute pancreatitis
title_full_unstemmed The effect of erythropoietin to pulmonary injury and mast cells secondary to acute pancreatitis
title_short The effect of erythropoietin to pulmonary injury and mast cells secondary to acute pancreatitis
title_sort effect of erythropoietin to pulmonary injury and mast cells secondary to acute pancreatitis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004514/
https://www.ncbi.nlm.nih.gov/pubmed/24761770
http://dx.doi.org/10.1186/1756-0500-7-267
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