Toll-like receptor genetic variants and colorectal cancer

Single-nucleotide polymorphisms in Toll-like receptor 5 (TLR5), encoding a sensor for flagellin, have been shown to influence cytokine responses to intestinal bacteria and to be associated with significant alterations in the survival of colorectal carcinoma (CRC) patients. These findings point to a...

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Detalles Bibliográficos
Autores principales: Weber, Alexander NR, Försti, Asta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004619/
https://www.ncbi.nlm.nih.gov/pubmed/24790794
http://dx.doi.org/10.4161/onci.27763
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author Weber, Alexander NR
Försti, Asta
author_facet Weber, Alexander NR
Försti, Asta
author_sort Weber, Alexander NR
collection PubMed
description Single-nucleotide polymorphisms in Toll-like receptor 5 (TLR5), encoding a sensor for flagellin, have been shown to influence cytokine responses to intestinal bacteria and to be associated with significant alterations in the survival of colorectal carcinoma (CRC) patients. These findings point to a link between TLRs and CRC that may have both therapeutic and prognostic/predictive implications.
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spelling pubmed-40046192015-01-10 Toll-like receptor genetic variants and colorectal cancer Weber, Alexander NR Försti, Asta Oncoimmunology Author's View Single-nucleotide polymorphisms in Toll-like receptor 5 (TLR5), encoding a sensor for flagellin, have been shown to influence cytokine responses to intestinal bacteria and to be associated with significant alterations in the survival of colorectal carcinoma (CRC) patients. These findings point to a link between TLRs and CRC that may have both therapeutic and prognostic/predictive implications. Landes Bioscience 2014-01-10 /pmc/articles/PMC4004619/ /pubmed/24790794 http://dx.doi.org/10.4161/onci.27763 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Weber, Alexander NR
Försti, Asta
Toll-like receptor genetic variants and colorectal cancer
title Toll-like receptor genetic variants and colorectal cancer
title_full Toll-like receptor genetic variants and colorectal cancer
title_fullStr Toll-like receptor genetic variants and colorectal cancer
title_full_unstemmed Toll-like receptor genetic variants and colorectal cancer
title_short Toll-like receptor genetic variants and colorectal cancer
title_sort toll-like receptor genetic variants and colorectal cancer
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004619/
https://www.ncbi.nlm.nih.gov/pubmed/24790794
http://dx.doi.org/10.4161/onci.27763
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