Understanding the influence of the tumor microenvironment on macrophage responses to CD40 agonists

Both T(H)1 and T(H)2 cytokines influence the antitumor functions of macrophages. We have recently shown that interferon γ (IFNγ) licenses the antineoplastic functions of CD40 ligand (CD40L)-stimulated macrophages more efficiently than interleukin (IL)-4 and IL-13. The presence of a T(H)1 and T(H)2 s...

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Detalles Bibliográficos
Autores principales: Luheshi, Nadia, Davies, Gareth, Legg, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004620/
https://www.ncbi.nlm.nih.gov/pubmed/24790792
http://dx.doi.org/10.4161/onci.27615
Descripción
Sumario:Both T(H)1 and T(H)2 cytokines influence the antitumor functions of macrophages. We have recently shown that interferon γ (IFNγ) licenses the antineoplastic functions of CD40 ligand (CD40L)-stimulated macrophages more efficiently than interleukin (IL)-4 and IL-13. The presence of a T(H)1 and T(H)2 skewed tumor microenvironment may therefore influence therapeutic responses to CD40 agonists, agents that are showing promise in preliminary clinical trials.

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