Understanding the influence of the tumor microenvironment on macrophage responses to CD40 agonists

Both T(H)1 and T(H)2 cytokines influence the antitumor functions of macrophages. We have recently shown that interferon γ (IFNγ) licenses the antineoplastic functions of CD40 ligand (CD40L)-stimulated macrophages more efficiently than interleukin (IL)-4 and IL-13. The presence of a T(H)1 and T(H)2 s...

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Detalles Bibliográficos
Autores principales: Luheshi, Nadia, Davies, Gareth, Legg, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004620/
https://www.ncbi.nlm.nih.gov/pubmed/24790792
http://dx.doi.org/10.4161/onci.27615
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author Luheshi, Nadia
Davies, Gareth
Legg, James
author_facet Luheshi, Nadia
Davies, Gareth
Legg, James
author_sort Luheshi, Nadia
collection PubMed
description Both T(H)1 and T(H)2 cytokines influence the antitumor functions of macrophages. We have recently shown that interferon γ (IFNγ) licenses the antineoplastic functions of CD40 ligand (CD40L)-stimulated macrophages more efficiently than interleukin (IL)-4 and IL-13. The presence of a T(H)1 and T(H)2 skewed tumor microenvironment may therefore influence therapeutic responses to CD40 agonists, agents that are showing promise in preliminary clinical trials.
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spelling pubmed-40046202014-04-30 Understanding the influence of the tumor microenvironment on macrophage responses to CD40 agonists Luheshi, Nadia Davies, Gareth Legg, James Oncoimmunology Author's View Both T(H)1 and T(H)2 cytokines influence the antitumor functions of macrophages. We have recently shown that interferon γ (IFNγ) licenses the antineoplastic functions of CD40 ligand (CD40L)-stimulated macrophages more efficiently than interleukin (IL)-4 and IL-13. The presence of a T(H)1 and T(H)2 skewed tumor microenvironment may therefore influence therapeutic responses to CD40 agonists, agents that are showing promise in preliminary clinical trials. Landes Bioscience 2014-01-06 /pmc/articles/PMC4004620/ /pubmed/24790792 http://dx.doi.org/10.4161/onci.27615 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Luheshi, Nadia
Davies, Gareth
Legg, James
Understanding the influence of the tumor microenvironment on macrophage responses to CD40 agonists
title Understanding the influence of the tumor microenvironment on macrophage responses to CD40 agonists
title_full Understanding the influence of the tumor microenvironment on macrophage responses to CD40 agonists
title_fullStr Understanding the influence of the tumor microenvironment on macrophage responses to CD40 agonists
title_full_unstemmed Understanding the influence of the tumor microenvironment on macrophage responses to CD40 agonists
title_short Understanding the influence of the tumor microenvironment on macrophage responses to CD40 agonists
title_sort understanding the influence of the tumor microenvironment on macrophage responses to cd40 agonists
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004620/
https://www.ncbi.nlm.nih.gov/pubmed/24790792
http://dx.doi.org/10.4161/onci.27615
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