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Relatively Small Birth Size and Accelerated Early Growth of Japanese Type 1 Diabetic Children with Younger Onset

We investigated the changes of anthropometrical parameters in Japanese children with type 1 diabetes (T1DM) from birth to the onset of diabetes. One-hundred ninety-nine children (79 males and 120 females) diagnosed between 0–16 yr of age during the period between 1990 and 2003 were the subjects of t...

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Autores principales: Kotani, Yumiko, Yokota, Ichiro, Kagami, Shoji, Amemiya, Shin, Matsuura, Nobuo, Sasaki, Nozomu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society for Pediatric Endocrinology 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004850/
https://www.ncbi.nlm.nih.gov/pubmed/24790324
http://dx.doi.org/10.1297/cpe.15.73
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author Kotani, Yumiko
Yokota, Ichiro
Kagami, Shoji
Amemiya, Shin
Matsuura, Nobuo
Sasaki, Nozomu
author_facet Kotani, Yumiko
Yokota, Ichiro
Kagami, Shoji
Amemiya, Shin
Matsuura, Nobuo
Sasaki, Nozomu
author_sort Kotani, Yumiko
collection PubMed
description We investigated the changes of anthropometrical parameters in Japanese children with type 1 diabetes (T1DM) from birth to the onset of diabetes. One-hundred ninety-nine children (79 males and 120 females) diagnosed between 0–16 yr of age during the period between 1990 and 2003 were the subjects of this study. The subjects were categorized into 3 groups according to onset age (0–5 yr; n=74, 5–10 yr; n=61, 10–16 yr; n=64). At birth, the younger onset (<5) group had significant lower height and weight standard deviation score (SDS) compared with the older onset (5≤) group (p=0.01 and p=0.02, respectively). When the changes in height SDS from birth to onset were compared, height SDS at onset were significantly greater than those at birth in the younger onset group (p<0.001). However, no significant difference was observed in the other groups (p=0.95 and p=0.39). These results suggest that relatively small size at birth and accelerated growth after birth until the onset of diabetes may be a characteristic of Japanese T1DM children with younger onset and may further support the hypothesis that emphasizes accelerated growth and subsequent insulin resistance as a cause of earlier onset of T1DM.
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spelling pubmed-40048502014-04-30 Relatively Small Birth Size and Accelerated Early Growth of Japanese Type 1 Diabetic Children with Younger Onset Kotani, Yumiko Yokota, Ichiro Kagami, Shoji Amemiya, Shin Matsuura, Nobuo Sasaki, Nozomu Clin Pediatr Endocrinol Original Article We investigated the changes of anthropometrical parameters in Japanese children with type 1 diabetes (T1DM) from birth to the onset of diabetes. One-hundred ninety-nine children (79 males and 120 females) diagnosed between 0–16 yr of age during the period between 1990 and 2003 were the subjects of this study. The subjects were categorized into 3 groups according to onset age (0–5 yr; n=74, 5–10 yr; n=61, 10–16 yr; n=64). At birth, the younger onset (<5) group had significant lower height and weight standard deviation score (SDS) compared with the older onset (5≤) group (p=0.01 and p=0.02, respectively). When the changes in height SDS from birth to onset were compared, height SDS at onset were significantly greater than those at birth in the younger onset group (p<0.001). However, no significant difference was observed in the other groups (p=0.95 and p=0.39). These results suggest that relatively small size at birth and accelerated growth after birth until the onset of diabetes may be a characteristic of Japanese T1DM children with younger onset and may further support the hypothesis that emphasizes accelerated growth and subsequent insulin resistance as a cause of earlier onset of T1DM. The Japanese Society for Pediatric Endocrinology 2006-04-29 2006 /pmc/articles/PMC4004850/ /pubmed/24790324 http://dx.doi.org/10.1297/cpe.15.73 Text en 2006©The Japanese Society for Pediatric Endocrinology http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
spellingShingle Original Article
Kotani, Yumiko
Yokota, Ichiro
Kagami, Shoji
Amemiya, Shin
Matsuura, Nobuo
Sasaki, Nozomu
Relatively Small Birth Size and Accelerated Early Growth of Japanese Type 1 Diabetic Children with Younger Onset
title Relatively Small Birth Size and Accelerated Early Growth of Japanese Type 1 Diabetic Children with Younger Onset
title_full Relatively Small Birth Size and Accelerated Early Growth of Japanese Type 1 Diabetic Children with Younger Onset
title_fullStr Relatively Small Birth Size and Accelerated Early Growth of Japanese Type 1 Diabetic Children with Younger Onset
title_full_unstemmed Relatively Small Birth Size and Accelerated Early Growth of Japanese Type 1 Diabetic Children with Younger Onset
title_short Relatively Small Birth Size and Accelerated Early Growth of Japanese Type 1 Diabetic Children with Younger Onset
title_sort relatively small birth size and accelerated early growth of japanese type 1 diabetic children with younger onset
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004850/
https://www.ncbi.nlm.nih.gov/pubmed/24790324
http://dx.doi.org/10.1297/cpe.15.73
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