Patients with Hypophosphatemic Osteomalacia Need Continuous Treatment during Adulthood

The treatment for hypophosphatemic rickets in children includes phosphate and vitamin D preparations. In children, this regimen significantly improves symptoms, while a treatment for adult patients has not been established. We therefore investigated the clinical courses of 15 adult patients who disc...

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Detalles Bibliográficos
Autores principales: Suzuki, Eri, Yamada, Makoto, Ariyasu, Daisuke, Izawa, Masako, Miyamoto, Junko, Koto, Shinobu, Hasegawa, Yukihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society for Pediatric Endocrinology 2009
Materias:
Original
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004881/
https://www.ncbi.nlm.nih.gov/pubmed/24790377
http://dx.doi.org/10.1297/cpe.18.29
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author Suzuki, Eri
Yamada, Makoto
Ariyasu, Daisuke
Izawa, Masako
Miyamoto, Junko
Koto, Shinobu
Hasegawa, Yukihiro
author_facet Suzuki, Eri
Yamada, Makoto
Ariyasu, Daisuke
Izawa, Masako
Miyamoto, Junko
Koto, Shinobu
Hasegawa, Yukihiro
author_sort Suzuki, Eri
collection PubMed
description The treatment for hypophosphatemic rickets in children includes phosphate and vitamin D preparations. In children, this regimen significantly improves symptoms, while a treatment for adult patients has not been established. We therefore investigated the clinical courses of 15 adult patients who discontinued therapy when final height was achieved in order to assess the necessity of treatment in adulthood. Thirteen patients developed symptomatic complications, including bone fractures. Among the 13, the 10 patients who restarted therapy all showed clinical improvement, and no side effects of treatment were observed. This study shows that there are some patients with hypophosphatemic osteomalacia who need continuous treatment during adulthood.
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spelling pubmed-40048812014-04-30 Patients with Hypophosphatemic Osteomalacia Need Continuous Treatment during Adulthood Suzuki, Eri Yamada, Makoto Ariyasu, Daisuke Izawa, Masako Miyamoto, Junko Koto, Shinobu Hasegawa, Yukihiro Clin Pediatr Endocrinol Original The treatment for hypophosphatemic rickets in children includes phosphate and vitamin D preparations. In children, this regimen significantly improves symptoms, while a treatment for adult patients has not been established. We therefore investigated the clinical courses of 15 adult patients who discontinued therapy when final height was achieved in order to assess the necessity of treatment in adulthood. Thirteen patients developed symptomatic complications, including bone fractures. Among the 13, the 10 patients who restarted therapy all showed clinical improvement, and no side effects of treatment were observed. This study shows that there are some patients with hypophosphatemic osteomalacia who need continuous treatment during adulthood. The Japanese Society for Pediatric Endocrinology 2009-02-19 2009 /pmc/articles/PMC4004881/ /pubmed/24790377 http://dx.doi.org/10.1297/cpe.18.29 Text en 2009©The Japanese Society for Pediatric Endocrinology http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
spellingShingle Original
Suzuki, Eri
Yamada, Makoto
Ariyasu, Daisuke
Izawa, Masako
Miyamoto, Junko
Koto, Shinobu
Hasegawa, Yukihiro
Patients with Hypophosphatemic Osteomalacia Need Continuous Treatment during Adulthood
title Patients with Hypophosphatemic Osteomalacia Need Continuous Treatment during Adulthood
title_full Patients with Hypophosphatemic Osteomalacia Need Continuous Treatment during Adulthood
title_fullStr Patients with Hypophosphatemic Osteomalacia Need Continuous Treatment during Adulthood
title_full_unstemmed Patients with Hypophosphatemic Osteomalacia Need Continuous Treatment during Adulthood
title_short Patients with Hypophosphatemic Osteomalacia Need Continuous Treatment during Adulthood
title_sort patients with hypophosphatemic osteomalacia need continuous treatment during adulthood
topic Original
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004881/
https://www.ncbi.nlm.nih.gov/pubmed/24790377
http://dx.doi.org/10.1297/cpe.18.29
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