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A Spectrum of Clinical Presentations in Seven Japanese Patients with Vitamin D Deficiency
Recently, the reemergence of vitamin D deficiency in developed countries has been pointed out. Vitamin D deficiency is diagnosed based on the serum 25-hydroxyvitamin D (25OHD) level. However, its normal range is still controversial, making the diagnosis of vitamin D deficiency difficult. Here, we pr...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society for Pediatric Endocrinology
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004900/ https://www.ncbi.nlm.nih.gov/pubmed/24790316 http://dx.doi.org/10.1297/cpe.15.23 |
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author | Kubota, Takuo Kotani, Tomoo Miyoshi, Yoko Santo, Yoko Hirai, Haruhiko Namba, Noriyuki Shima, Masaaki Shimizu, Kazuo Nakajima, Shigeo Ozono, Keiichi |
author_facet | Kubota, Takuo Kotani, Tomoo Miyoshi, Yoko Santo, Yoko Hirai, Haruhiko Namba, Noriyuki Shima, Masaaki Shimizu, Kazuo Nakajima, Shigeo Ozono, Keiichi |
author_sort | Kubota, Takuo |
collection | PubMed |
description | Recently, the reemergence of vitamin D deficiency in developed countries has been pointed out. Vitamin D deficiency is diagnosed based on the serum 25-hydroxyvitamin D (25OHD) level. However, its normal range is still controversial, making the diagnosis of vitamin D deficiency difficult. Here, we present seven Japanese patients diagnosed with vitamin D deficiency. Three patients complained of leg bowing, and the other four of tetany. The patients with leg bowing were toddlers. Radiographic surveys demonstrated evidence of rickets. Laboratory findings showed decreased levels of serum inorganic phosphorus and increased levels of alkaline phosphatase (ALP) and intact-parathyroid hormone (iPTH). The serum levels of 25OHD were relatively low, ranging from 13 to 15.2 ng/ml. Of the patients with tetany, three were young infants. Laboratory findings showed decreased levels of serum calcium and increased levels of ALP and iPTH. The serum levels of 25OHD were markedly decreased (below 8 ng/ml). Thus, these results indicate that relatively low levels of 25OHD can cause rickets, a symptom of vitamin D deficiency, and that clinicians should therefore carefully evaluate the levels of 25OHD. |
format | Online Article Text |
id | pubmed-4004900 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | The Japanese Society for Pediatric Endocrinology |
record_format | MEDLINE/PubMed |
spelling | pubmed-40049002014-04-30 A Spectrum of Clinical Presentations in Seven Japanese Patients with Vitamin D Deficiency Kubota, Takuo Kotani, Tomoo Miyoshi, Yoko Santo, Yoko Hirai, Haruhiko Namba, Noriyuki Shima, Masaaki Shimizu, Kazuo Nakajima, Shigeo Ozono, Keiichi Clin Pediatr Endocrinol Original Article Recently, the reemergence of vitamin D deficiency in developed countries has been pointed out. Vitamin D deficiency is diagnosed based on the serum 25-hydroxyvitamin D (25OHD) level. However, its normal range is still controversial, making the diagnosis of vitamin D deficiency difficult. Here, we present seven Japanese patients diagnosed with vitamin D deficiency. Three patients complained of leg bowing, and the other four of tetany. The patients with leg bowing were toddlers. Radiographic surveys demonstrated evidence of rickets. Laboratory findings showed decreased levels of serum inorganic phosphorus and increased levels of alkaline phosphatase (ALP) and intact-parathyroid hormone (iPTH). The serum levels of 25OHD were relatively low, ranging from 13 to 15.2 ng/ml. Of the patients with tetany, three were young infants. Laboratory findings showed decreased levels of serum calcium and increased levels of ALP and iPTH. The serum levels of 25OHD were markedly decreased (below 8 ng/ml). Thus, these results indicate that relatively low levels of 25OHD can cause rickets, a symptom of vitamin D deficiency, and that clinicians should therefore carefully evaluate the levels of 25OHD. The Japanese Society for Pediatric Endocrinology 2006-02-22 2006 /pmc/articles/PMC4004900/ /pubmed/24790316 http://dx.doi.org/10.1297/cpe.15.23 Text en 2006©The Japanese Society for Pediatric Endocrinology http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. |
spellingShingle | Original Article Kubota, Takuo Kotani, Tomoo Miyoshi, Yoko Santo, Yoko Hirai, Haruhiko Namba, Noriyuki Shima, Masaaki Shimizu, Kazuo Nakajima, Shigeo Ozono, Keiichi A Spectrum of Clinical Presentations in Seven Japanese Patients with Vitamin D Deficiency |
title | A Spectrum of Clinical Presentations in Seven Japanese Patients with Vitamin
D Deficiency |
title_full | A Spectrum of Clinical Presentations in Seven Japanese Patients with Vitamin
D Deficiency |
title_fullStr | A Spectrum of Clinical Presentations in Seven Japanese Patients with Vitamin
D Deficiency |
title_full_unstemmed | A Spectrum of Clinical Presentations in Seven Japanese Patients with Vitamin
D Deficiency |
title_short | A Spectrum of Clinical Presentations in Seven Japanese Patients with Vitamin
D Deficiency |
title_sort | spectrum of clinical presentations in seven japanese patients with vitamin
d deficiency |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004900/ https://www.ncbi.nlm.nih.gov/pubmed/24790316 http://dx.doi.org/10.1297/cpe.15.23 |
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