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Intramuscular Midazolam for Pediatric Sedation in the Emergency Department: A Short Communication on Clinical Safety and Effectiveness

BACKGROUND: Procedural sedation in children continues to be a problem in the emergency department (ED). Midazolam is the first water-soluble benzodiazepine and it has been widely used for procedural sedation in pediatric patients. OBJECTIVES: The aim of this study was evaluation of clinical safety a...

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Autores principales: Ghane, Mohammad Reza, Musavi Vaezi, Seyed Yasin, Hedayati Asl, Amir Abbas, Javadzadeh, Hamid Reza, Mahmoudi, Sadrollah, Saburi, Amin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kowsar 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004986/
https://www.ncbi.nlm.nih.gov/pubmed/24829888
http://dx.doi.org/10.5812/traumamon.3458
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author Ghane, Mohammad Reza
Musavi Vaezi, Seyed Yasin
Hedayati Asl, Amir Abbas
Javadzadeh, Hamid Reza
Mahmoudi, Sadrollah
Saburi, Amin
author_facet Ghane, Mohammad Reza
Musavi Vaezi, Seyed Yasin
Hedayati Asl, Amir Abbas
Javadzadeh, Hamid Reza
Mahmoudi, Sadrollah
Saburi, Amin
author_sort Ghane, Mohammad Reza
collection PubMed
description BACKGROUND: Procedural sedation in children continues to be a problem in the emergency department (ED). Midazolam is the first water-soluble benzodiazepine and it has been widely used for procedural sedation in pediatric patients. OBJECTIVES: The aim of this study was evaluation of clinical safety and effectiveness of intramuscular Midazolam for pediatric sedation in the ED setting. MATERIALS AND METHODS: We performed a self-controlled clinical trial on 30 children who referred to the Baqiyatallah Hospital ED between 2009 and 2010. They received intramuscular Midazolam 0.3 mg/kg for procedural sedation and then they were followed for sedative effectiveness and safety. Vital signs and O2 saturation were also observed. The findings were compared using SPSS ver. 16 software. RESULTS: The mean age was 5.50 ± 2.70 years, the mean weight was 19.50 ± 6.63 kilograms and 16 patients (53.3%) were females. The most common adverse effect was euphoria (66.66%) and vertigo (6.7%); 27.7% did not show any side effects. There was an overall complication rate of 72.3%. The vital signs including heart rate, respiratory rate, systolic and diastolic blood pressure and O2 saturation decreased significantly during sedation (P value < 0.05). CONCLUSIONS: Midazolam is an effective and relatively safe sedative for pediatric patients in the ED. The patient should be observed closely and monitored for psychological and hemodynamic side effects.
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spelling pubmed-40049862014-05-14 Intramuscular Midazolam for Pediatric Sedation in the Emergency Department: A Short Communication on Clinical Safety and Effectiveness Ghane, Mohammad Reza Musavi Vaezi, Seyed Yasin Hedayati Asl, Amir Abbas Javadzadeh, Hamid Reza Mahmoudi, Sadrollah Saburi, Amin Trauma Mon Original Article BACKGROUND: Procedural sedation in children continues to be a problem in the emergency department (ED). Midazolam is the first water-soluble benzodiazepine and it has been widely used for procedural sedation in pediatric patients. OBJECTIVES: The aim of this study was evaluation of clinical safety and effectiveness of intramuscular Midazolam for pediatric sedation in the ED setting. MATERIALS AND METHODS: We performed a self-controlled clinical trial on 30 children who referred to the Baqiyatallah Hospital ED between 2009 and 2010. They received intramuscular Midazolam 0.3 mg/kg for procedural sedation and then they were followed for sedative effectiveness and safety. Vital signs and O2 saturation were also observed. The findings were compared using SPSS ver. 16 software. RESULTS: The mean age was 5.50 ± 2.70 years, the mean weight was 19.50 ± 6.63 kilograms and 16 patients (53.3%) were females. The most common adverse effect was euphoria (66.66%) and vertigo (6.7%); 27.7% did not show any side effects. There was an overall complication rate of 72.3%. The vital signs including heart rate, respiratory rate, systolic and diastolic blood pressure and O2 saturation decreased significantly during sedation (P value < 0.05). CONCLUSIONS: Midazolam is an effective and relatively safe sedative for pediatric patients in the ED. The patient should be observed closely and monitored for psychological and hemodynamic side effects. Kowsar 2012-05-26 2012 /pmc/articles/PMC4004986/ /pubmed/24829888 http://dx.doi.org/10.5812/traumamon.3458 Text en Copyright ©2012, Kowsar Corp. All rights reserved. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Ghane, Mohammad Reza
Musavi Vaezi, Seyed Yasin
Hedayati Asl, Amir Abbas
Javadzadeh, Hamid Reza
Mahmoudi, Sadrollah
Saburi, Amin
Intramuscular Midazolam for Pediatric Sedation in the Emergency Department: A Short Communication on Clinical Safety and Effectiveness
title Intramuscular Midazolam for Pediatric Sedation in the Emergency Department: A Short Communication on Clinical Safety and Effectiveness
title_full Intramuscular Midazolam for Pediatric Sedation in the Emergency Department: A Short Communication on Clinical Safety and Effectiveness
title_fullStr Intramuscular Midazolam for Pediatric Sedation in the Emergency Department: A Short Communication on Clinical Safety and Effectiveness
title_full_unstemmed Intramuscular Midazolam for Pediatric Sedation in the Emergency Department: A Short Communication on Clinical Safety and Effectiveness
title_short Intramuscular Midazolam for Pediatric Sedation in the Emergency Department: A Short Communication on Clinical Safety and Effectiveness
title_sort intramuscular midazolam for pediatric sedation in the emergency department: a short communication on clinical safety and effectiveness
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004986/
https://www.ncbi.nlm.nih.gov/pubmed/24829888
http://dx.doi.org/10.5812/traumamon.3458
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