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Human Antibody Response to Aedes albopictus Salivary Proteins: A Potential Biomarker to Evaluate the Efficacy of Vector Control in an Area of Chikungunya and Dengue Virus Transmission

Aedes borne viruses represent public health problems in southern countries and threat to emerge in the developed world. Their control is currently based on vector population control. Much effort is being devoted to develop new tools to control such arbovirus. Recent findings suggest that the evaluat...

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Autores principales: Doucoure, Souleymane, Mouchet, François, Cornelie, Sylvie, Drame, Papa Makhtar, D'Ortenzio, Eric, DeHecq, Jean Sébastien, Remoue, Franck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005104/
https://www.ncbi.nlm.nih.gov/pubmed/24822216
http://dx.doi.org/10.1155/2014/746509
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author Doucoure, Souleymane
Mouchet, François
Cornelie, Sylvie
Drame, Papa Makhtar
D'Ortenzio, Eric
DeHecq, Jean Sébastien
Remoue, Franck
author_facet Doucoure, Souleymane
Mouchet, François
Cornelie, Sylvie
Drame, Papa Makhtar
D'Ortenzio, Eric
DeHecq, Jean Sébastien
Remoue, Franck
author_sort Doucoure, Souleymane
collection PubMed
description Aedes borne viruses represent public health problems in southern countries and threat to emerge in the developed world. Their control is currently based on vector population control. Much effort is being devoted to develop new tools to control such arbovirus. Recent findings suggest that the evaluation of human antibody (Ab) response to arthropod salivary proteins is relevant to measuring the level of human exposure to mosquito bites. Using an immunoepidemiological approach, the present study aimed to assess the usefulness of the salivary biomarker for measuring the efficacy of Ae. albopictus control strategies in La Reunion urban area. The antisaliva Ab response of adult humans exposed to Ae. albopictus was evaluatedbefore and after vector control measures. Our results showed a significant correlation between antisaliva Ab response and the level of exposure to vectors bites. The decrease of Ae. albopictus density has been detected by this biomarker two weeks after the implementation of control measures, suggesting its potential usefulness for evaluating control strategies in a short time period. The identification of species specific salivary proteins/peptides should improve the use of this biomarker.
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spelling pubmed-40051042014-05-12 Human Antibody Response to Aedes albopictus Salivary Proteins: A Potential Biomarker to Evaluate the Efficacy of Vector Control in an Area of Chikungunya and Dengue Virus Transmission Doucoure, Souleymane Mouchet, François Cornelie, Sylvie Drame, Papa Makhtar D'Ortenzio, Eric DeHecq, Jean Sébastien Remoue, Franck Biomed Res Int Research Article Aedes borne viruses represent public health problems in southern countries and threat to emerge in the developed world. Their control is currently based on vector population control. Much effort is being devoted to develop new tools to control such arbovirus. Recent findings suggest that the evaluation of human antibody (Ab) response to arthropod salivary proteins is relevant to measuring the level of human exposure to mosquito bites. Using an immunoepidemiological approach, the present study aimed to assess the usefulness of the salivary biomarker for measuring the efficacy of Ae. albopictus control strategies in La Reunion urban area. The antisaliva Ab response of adult humans exposed to Ae. albopictus was evaluatedbefore and after vector control measures. Our results showed a significant correlation between antisaliva Ab response and the level of exposure to vectors bites. The decrease of Ae. albopictus density has been detected by this biomarker two weeks after the implementation of control measures, suggesting its potential usefulness for evaluating control strategies in a short time period. The identification of species specific salivary proteins/peptides should improve the use of this biomarker. Hindawi Publishing Corporation 2014 2014-04-13 /pmc/articles/PMC4005104/ /pubmed/24822216 http://dx.doi.org/10.1155/2014/746509 Text en Copyright © 2014 Souleymane Doucoure et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Doucoure, Souleymane
Mouchet, François
Cornelie, Sylvie
Drame, Papa Makhtar
D'Ortenzio, Eric
DeHecq, Jean Sébastien
Remoue, Franck
Human Antibody Response to Aedes albopictus Salivary Proteins: A Potential Biomarker to Evaluate the Efficacy of Vector Control in an Area of Chikungunya and Dengue Virus Transmission
title Human Antibody Response to Aedes albopictus Salivary Proteins: A Potential Biomarker to Evaluate the Efficacy of Vector Control in an Area of Chikungunya and Dengue Virus Transmission
title_full Human Antibody Response to Aedes albopictus Salivary Proteins: A Potential Biomarker to Evaluate the Efficacy of Vector Control in an Area of Chikungunya and Dengue Virus Transmission
title_fullStr Human Antibody Response to Aedes albopictus Salivary Proteins: A Potential Biomarker to Evaluate the Efficacy of Vector Control in an Area of Chikungunya and Dengue Virus Transmission
title_full_unstemmed Human Antibody Response to Aedes albopictus Salivary Proteins: A Potential Biomarker to Evaluate the Efficacy of Vector Control in an Area of Chikungunya and Dengue Virus Transmission
title_short Human Antibody Response to Aedes albopictus Salivary Proteins: A Potential Biomarker to Evaluate the Efficacy of Vector Control in an Area of Chikungunya and Dengue Virus Transmission
title_sort human antibody response to aedes albopictus salivary proteins: a potential biomarker to evaluate the efficacy of vector control in an area of chikungunya and dengue virus transmission
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005104/
https://www.ncbi.nlm.nih.gov/pubmed/24822216
http://dx.doi.org/10.1155/2014/746509
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