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Comparative study of in vitro release and mucoadhesivity of gastric compacts composed of multiple unit system/bilayered discs using direct compression of metformin hydrochloride
Introduction: Metformin is an oral anti-diabetic drug in the biguanide class. The goal of this study was to develop gastric-retentive MH discs in order to prolong the retention of drug in gastric mucosa. Methods: Two groups of metformin hydrochloride (MH) mucoadhesive gastroretentive discs were prep...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Tabriz University of Medical Sciences
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005280/ https://www.ncbi.nlm.nih.gov/pubmed/24790896 http://dx.doi.org/10.5681/bi.2014.002 |