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Analgesic, anti-inflammatory and anti-pyretic activities of Caesalpinia decapetala

Introduction: In many pathological conditions, pain, inflammation and fever are interdependent to each other. Due to the use of synthetic drugs, many unwanted effects usually appear. Various studies have been conducted on Caesalpinia decapetala (C. decapetala) to evaluate its effects in the treatmen...

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Autores principales: Parveen, Amna, Sajid Hamid Akash, Muhammad, Rehman, Kanwal, Mahmood, Qaisar, Qadir, Muhammad Imran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tabriz University of Medical Sciences 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005283/
https://www.ncbi.nlm.nih.gov/pubmed/24790898
http://dx.doi.org/10.5681/bi.2014.013
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author Parveen, Amna
Sajid Hamid Akash, Muhammad
Rehman, Kanwal
Mahmood, Qaisar
Qadir, Muhammad Imran
author_facet Parveen, Amna
Sajid Hamid Akash, Muhammad
Rehman, Kanwal
Mahmood, Qaisar
Qadir, Muhammad Imran
author_sort Parveen, Amna
collection PubMed
description Introduction: In many pathological conditions, pain, inflammation and fever are interdependent to each other. Due to the use of synthetic drugs, many unwanted effects usually appear. Various studies have been conducted on Caesalpinia decapetala (C. decapetala) to evaluate its effects in the treatment of various diseases but no sufficient scientific literature is available online to prove its analgesic, anti-inflammatory and anti-pyretic activities. Methods: The analgesic, anti-inflammatory and anti-pyretic activities of 70% aqueous methanolic and n-hexane extracts of C. decapetala was evaluated using Swiss albino mice (20-30 g). Results: The results showed that aqueous methanolic extract of C. decapetala at the dose of 100 mg/kg exhibited significant (p< 0.05) activities in various pain models including acetic acid-induced writhing (18.4 ± 0.53), formalin-induced licking (275 ± 4.18) and hot plate method (2.3 ± 0.0328); whereas,  n-hexane extract showed its effects in acetic acid-induced writhing (20 ± 0.31), formalin-induced licking (293 ± 1.20) and hot plate method (2.224 ± 0.029) compared to the effects observed in control group animals. Similarly, the aqueous methanolic extract of C. decapetala after 2 h of treatment exhibited more significant anti-inflammatory (0.66 ± 0.06) and anti-pyretic (38.81 ± 0.05) activities compared to the control group animals. Conclusion: From the findings of our present study, we concluded that the aqueous methanolic extract of C. decapetala has stronger analgesic, anti-inflammatory and anti-pyretic effects than its n-hexane extract. Further studies are required to investigate the active constituents of C. decapetala that exhibit analgesic, anti-inflammatory and anti-pyretic activities.
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spelling pubmed-40052832014-04-30 Analgesic, anti-inflammatory and anti-pyretic activities of Caesalpinia decapetala Parveen, Amna Sajid Hamid Akash, Muhammad Rehman, Kanwal Mahmood, Qaisar Qadir, Muhammad Imran Bioimpacts Research Article Introduction: In many pathological conditions, pain, inflammation and fever are interdependent to each other. Due to the use of synthetic drugs, many unwanted effects usually appear. Various studies have been conducted on Caesalpinia decapetala (C. decapetala) to evaluate its effects in the treatment of various diseases but no sufficient scientific literature is available online to prove its analgesic, anti-inflammatory and anti-pyretic activities. Methods: The analgesic, anti-inflammatory and anti-pyretic activities of 70% aqueous methanolic and n-hexane extracts of C. decapetala was evaluated using Swiss albino mice (20-30 g). Results: The results showed that aqueous methanolic extract of C. decapetala at the dose of 100 mg/kg exhibited significant (p< 0.05) activities in various pain models including acetic acid-induced writhing (18.4 ± 0.53), formalin-induced licking (275 ± 4.18) and hot plate method (2.3 ± 0.0328); whereas,  n-hexane extract showed its effects in acetic acid-induced writhing (20 ± 0.31), formalin-induced licking (293 ± 1.20) and hot plate method (2.224 ± 0.029) compared to the effects observed in control group animals. Similarly, the aqueous methanolic extract of C. decapetala after 2 h of treatment exhibited more significant anti-inflammatory (0.66 ± 0.06) and anti-pyretic (38.81 ± 0.05) activities compared to the control group animals. Conclusion: From the findings of our present study, we concluded that the aqueous methanolic extract of C. decapetala has stronger analgesic, anti-inflammatory and anti-pyretic effects than its n-hexane extract. Further studies are required to investigate the active constituents of C. decapetala that exhibit analgesic, anti-inflammatory and anti-pyretic activities. Tabriz University of Medical Sciences 2014 2014-04-10 /pmc/articles/PMC4005283/ /pubmed/24790898 http://dx.doi.org/10.5681/bi.2014.013 Text en © 2014 The Author(s) This work is published by BioImpacts as an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/). Non-commercial uses of the work are permitted, provided the original work is properly cited.
spellingShingle Research Article
Parveen, Amna
Sajid Hamid Akash, Muhammad
Rehman, Kanwal
Mahmood, Qaisar
Qadir, Muhammad Imran
Analgesic, anti-inflammatory and anti-pyretic activities of Caesalpinia decapetala
title Analgesic, anti-inflammatory and anti-pyretic activities of Caesalpinia decapetala
title_full Analgesic, anti-inflammatory and anti-pyretic activities of Caesalpinia decapetala
title_fullStr Analgesic, anti-inflammatory and anti-pyretic activities of Caesalpinia decapetala
title_full_unstemmed Analgesic, anti-inflammatory and anti-pyretic activities of Caesalpinia decapetala
title_short Analgesic, anti-inflammatory and anti-pyretic activities of Caesalpinia decapetala
title_sort analgesic, anti-inflammatory and anti-pyretic activities of caesalpinia decapetala
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005283/
https://www.ncbi.nlm.nih.gov/pubmed/24790898
http://dx.doi.org/10.5681/bi.2014.013
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