The transcription factor DREAM represses A20 and mediates inflammation

Here we show that the transcription-repressor DREAM binds to the A20 promoter to repress the expression of A20, the deubiquitinase suppressing inflammatory NF-κB signaling. DREAM-deficient (Dream(−/−)) mice displayed persistent and unchecked A20 expression in response to endotoxin. DREAM functioned...

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Detalles Bibliográficos
Autores principales: Tiruppathi, Chinnaswamy, Soni, Dheeraj, Wang, Dong-Mei, Xue, Jiaping, Singh, Vandana, Thippegowda, Prabhakar B., Cheppudira, Bopaiah P., Mishra, Rakesh K., DebRoy, Auditi, Qian, Zhijian, Bachmaier, Kurt, Zhao, Youyang, Christman, John W., Vogel, Stephen M., Ma, Averil, Malik, Asrar B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005385/
https://www.ncbi.nlm.nih.gov/pubmed/24487321
http://dx.doi.org/10.1038/ni.2823

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