Proof of principle: quality control of therapeutic cell preparations using senescence-associated DNA-methylation changes

BACKGROUND: Tracking of replicative senescence is of fundamental relevance in cellular therapy. Cell preparations – such as mesenchymal stromal cells (MSCs) - undergo continuous changes during culture expansion, which is reflected by impaired proliferation and loss of differentiation potential. This...

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Detalles Bibliográficos
Autores principales: Schellenberg, Anne, Mauen, Sébastien, Koch, Carmen Mareike, Jans, Ralph, de Waele, Peter, Wagner, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005405/
https://www.ncbi.nlm.nih.gov/pubmed/24755407
http://dx.doi.org/10.1186/1756-0500-7-254

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