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Vitamin D deficiency in children and adolescents submitted to hematopoietic stem cell transplantation
BACKGROUND: Sub-optimal levels of vitamin D have been found to be highly prevalent in all age groups, with epidemiologic studies demonstrating a link between vitamin D deficiency and disease susceptibility, such as infection and cancer, and mortality rates. In adult transplant patients, it has been...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Hematologia e Hemoterapia
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005511/ https://www.ncbi.nlm.nih.gov/pubmed/24790538 http://dx.doi.org/10.5581/1516-8484.20140029 |
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author | Campos, Denise Johnsson Kujew Biagini, Gleyne Lopes Moreira Funke, Vaneuza Araujo Sales Bonfim, Carmem Maria Boguszewski, César Luiz Cochenski Borba, Victória Zeghbi |
author_facet | Campos, Denise Johnsson Kujew Biagini, Gleyne Lopes Moreira Funke, Vaneuza Araujo Sales Bonfim, Carmem Maria Boguszewski, César Luiz Cochenski Borba, Victória Zeghbi |
author_sort | Campos, Denise Johnsson |
collection | PubMed |
description | BACKGROUND: Sub-optimal levels of vitamin D have been found to be highly prevalent in all age groups, with epidemiologic studies demonstrating a link between vitamin D deficiency and disease susceptibility, such as infection and cancer, and mortality rates. In adult transplant patients, it has been suggested that the immunomodulatory properties of vitamin D may have an important role in the prevention and treatment of graft-versus-host disease. OBJECTIVE: The objective of this study was to assess serum 25-hydroxyvitamin D levels of children and adolescents submitted to allogeneic hematopoietic stem cell transplantation. Methods: Serum 25-hydroxyvitamin D levels of 66 patients, aged 4-20 years, were assessed at three stages: before hospitalization for hematopoietic stem cell transplantation and at 30 and 180 days after hematopoietic stem cell transplantation. The control group consisted of 25 healthy children. RESULTS: At the pre-hematopoietic stem cell transplantation stage, patients had lower levels of 25-hydroxyvitamin D compared to controls (25.7 ± 12.3 ng/mL vs. 31.9 ± 9.9 ng/mL; p-value = 0.01), and a higher prevalence of 25-hydroxyvitamin D deficiency (32% vs. 8%; p-value = 0.01). Prevalence increased significantly after hematopoietic stem cell transplantation (p-value = 0.01) with half of the patients having vitamin D deficiency at 180 days after transplantation. At this stage, mean serum 25-hydroxyvitamin D levels were 20.9 ± 10.9 ng/mL, a significant decline in relation to baseline (p-value = 0.01). No correlation was found between 25-hydroxyvitamin D levels and vitamin D intake, graft-versus-host disease, corticoid use or survival rates. CONCLUSION: Low levels of 25-hydroxyvitamin D were detected even before hematopoietic stem cell transplantation and were significantly lower at 180 days after hematopoietic stem cell transplantation, thus recommending vitamin D supplementation for children and adolescents submitted to hematopoietic stem cell transplantation. |
format | Online Article Text |
id | pubmed-4005511 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Sociedade Brasileira de Hematologia e Hemoterapia |
record_format | MEDLINE/PubMed |
spelling | pubmed-40055112014-04-30 Vitamin D deficiency in children and adolescents submitted to hematopoietic stem cell transplantation Campos, Denise Johnsson Kujew Biagini, Gleyne Lopes Moreira Funke, Vaneuza Araujo Sales Bonfim, Carmem Maria Boguszewski, César Luiz Cochenski Borba, Victória Zeghbi Rev Bras Hematol Hemoter Original article BACKGROUND: Sub-optimal levels of vitamin D have been found to be highly prevalent in all age groups, with epidemiologic studies demonstrating a link between vitamin D deficiency and disease susceptibility, such as infection and cancer, and mortality rates. In adult transplant patients, it has been suggested that the immunomodulatory properties of vitamin D may have an important role in the prevention and treatment of graft-versus-host disease. OBJECTIVE: The objective of this study was to assess serum 25-hydroxyvitamin D levels of children and adolescents submitted to allogeneic hematopoietic stem cell transplantation. Methods: Serum 25-hydroxyvitamin D levels of 66 patients, aged 4-20 years, were assessed at three stages: before hospitalization for hematopoietic stem cell transplantation and at 30 and 180 days after hematopoietic stem cell transplantation. The control group consisted of 25 healthy children. RESULTS: At the pre-hematopoietic stem cell transplantation stage, patients had lower levels of 25-hydroxyvitamin D compared to controls (25.7 ± 12.3 ng/mL vs. 31.9 ± 9.9 ng/mL; p-value = 0.01), and a higher prevalence of 25-hydroxyvitamin D deficiency (32% vs. 8%; p-value = 0.01). Prevalence increased significantly after hematopoietic stem cell transplantation (p-value = 0.01) with half of the patients having vitamin D deficiency at 180 days after transplantation. At this stage, mean serum 25-hydroxyvitamin D levels were 20.9 ± 10.9 ng/mL, a significant decline in relation to baseline (p-value = 0.01). No correlation was found between 25-hydroxyvitamin D levels and vitamin D intake, graft-versus-host disease, corticoid use or survival rates. CONCLUSION: Low levels of 25-hydroxyvitamin D were detected even before hematopoietic stem cell transplantation and were significantly lower at 180 days after hematopoietic stem cell transplantation, thus recommending vitamin D supplementation for children and adolescents submitted to hematopoietic stem cell transplantation. Sociedade Brasileira de Hematologia e Hemoterapia 2014 2014-07-08 /pmc/articles/PMC4005511/ /pubmed/24790538 http://dx.doi.org/10.5581/1516-8484.20140029 Text en © 2014 Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier Editora Ltda. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/). |
spellingShingle | Original article Campos, Denise Johnsson Kujew Biagini, Gleyne Lopes Moreira Funke, Vaneuza Araujo Sales Bonfim, Carmem Maria Boguszewski, César Luiz Cochenski Borba, Victória Zeghbi Vitamin D deficiency in children and adolescents submitted to hematopoietic stem cell transplantation |
title | Vitamin D deficiency in children and adolescents submitted to hematopoietic stem cell transplantation |
title_full | Vitamin D deficiency in children and adolescents submitted to hematopoietic stem cell transplantation |
title_fullStr | Vitamin D deficiency in children and adolescents submitted to hematopoietic stem cell transplantation |
title_full_unstemmed | Vitamin D deficiency in children and adolescents submitted to hematopoietic stem cell transplantation |
title_short | Vitamin D deficiency in children and adolescents submitted to hematopoietic stem cell transplantation |
title_sort | vitamin d deficiency in children and adolescents submitted to hematopoietic stem cell transplantation |
topic | Original article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005511/ https://www.ncbi.nlm.nih.gov/pubmed/24790538 http://dx.doi.org/10.5581/1516-8484.20140029 |
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