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Conditional DNA repair mutants enable highly precise genome engineering
Oligonucleotide-mediated multiplex genome engineering is an important tool for bacterial genome editing. The efficient application of this technique requires the inactivation of the endogenous methyl-directed mismatch repair system that in turn leads to a drastically elevated genomic mutation rate a...
Autores principales: | Nyerges, Ákos, Csörgő, Bálint, Nagy, István, Latinovics, Dóra, Szamecz, Béla, Pósfai, György, Pál, Csaba |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005651/ https://www.ncbi.nlm.nih.gov/pubmed/24500200 http://dx.doi.org/10.1093/nar/gku105 |
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