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Sudemycin E influences alternative splicing and changes chromatin modifications

Sudemycin E is an analog of the pre-messenger RNA splicing modulator FR901464 and its derivative spliceostatin A. Sudemycin E causes the death of cancer cells through an unknown mechanism. We found that similar to spliceostatin A, sudemycin E binds to the U2 small nuclear ribonucleoprotein (snRNP) c...

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Detalles Bibliográficos
Autores principales:	Convertini, Paolo, Shen, Manli, Potter, Philip M., Palacios, Gustavo, Lagisetti, Chandraiah, de la Grange, Pierre, Horbinski, Craig, Fondufe-Mittendorf, Yvonne N., Webb, Thomas R., Stamm, Stefan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Gene Regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005683/ https://www.ncbi.nlm.nih.gov/pubmed/24623796 http://dx.doi.org/10.1093/nar/gku151

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