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Integrase residues that determine nucleotide preferences at sites of HIV-1 integration: implications for the mechanism of target DNA binding

Retroviruses favor target-DNA (tDNA) distortion and particular bases at sites of integration, but the mechanism underlying HIV-1 selectivity is unknown. Crystal structures revealed a network of prototype foamy virus (PFV) integrase residues that distort tDNA: Ala188 and Arg329 interact with tDNA bas...

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Detalles Bibliográficos
Autores principales:	Serrao, Erik, Krishnan, Lavanya, Shun, Ming-Chieh, Li, Xiang, Cherepanov, Peter, Engelman, Alan, Maertens, Goedele N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005685/ https://www.ncbi.nlm.nih.gov/pubmed/24520116 http://dx.doi.org/10.1093/nar/gku136

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