Cargando…

Mapping Small-World Properties through Development in the Human Brain: Disruption in Schizophrenia

Evidence from imaging studies suggests that the human brain has a small-world network topology that might be disrupted in certain brain disorders. However, current methodology is based on global graph theory measures, such as clustering, C, characteristic path length, L, and small-worldness, S, that...

Descripción completa

Detalles Bibliográficos
Autores principales: Tomasi, Dardo, Volkow, Nora D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005771/
https://www.ncbi.nlm.nih.gov/pubmed/24788815
http://dx.doi.org/10.1371/journal.pone.0096176
_version_ 1782314154742251520
author Tomasi, Dardo
Volkow, Nora D.
author_facet Tomasi, Dardo
Volkow, Nora D.
author_sort Tomasi, Dardo
collection PubMed
description Evidence from imaging studies suggests that the human brain has a small-world network topology that might be disrupted in certain brain disorders. However, current methodology is based on global graph theory measures, such as clustering, C, characteristic path length, L, and small-worldness, S, that lack spatial specificity and are insufficient to identify regional brain abnormalities. Here we propose novel ultra-fast methodology for mapping local properties of brain network topology such as local C, L and S (lC, lL and lS) in the human brain at 3-mm isotropic resolution from ‘resting-state’ magnetic resonance imaging data. Test-retest datasets from 40 healthy children/adolescents were used to demonstrate the overall good reliability of the measures across sessions and computational parameters (intraclass correlation > 0.5 for lC and lL) and their low variability across subjects (< 29%). Whereas regions with high local functional connectivity density (lFCD; local degree) in posterior parietal and occipital cortices demonstrated high lC and short lL, subcortical regions (globus pallidus, thalamus, hippocampus and amygdala), cerebellum (lobes and vermis), cingulum and temporal cortex also had high, lS, demonstrating stronger small-world topology than other hubs. Children/adolescents had stronger lFCD, higher lC and longer lL in most cortical regions and thalamus than 74 healthy adults, consistent with pruning of functional connectivity during maturation. In contrast, lFCD, lC and lL were weaker in thalamus and midbrain, and lL was shorter in frontal cortical regions and cerebellum for 69 schizophrenia patients than for 74 healthy controls, suggesting exaggerated pruning of connectivity in schizophrenia. Follow up correlation analyses for seeds in thalamus and midbrain uncovered lower positive connectivity of these regions in thalamus, putamen, cerebellum and frontal cortex (cingulum, orbitofrontal, inferior frontal) and lower negative connectivity in auditory, visual, motor, premotor and somatosensory cortices for schizophrenia patients than for controls, consistent with prior findings of thalamic disconnection in schizophrenia.
format Online
Article
Text
id pubmed-4005771
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-40057712014-05-09 Mapping Small-World Properties through Development in the Human Brain: Disruption in Schizophrenia Tomasi, Dardo Volkow, Nora D. PLoS One Research Article Evidence from imaging studies suggests that the human brain has a small-world network topology that might be disrupted in certain brain disorders. However, current methodology is based on global graph theory measures, such as clustering, C, characteristic path length, L, and small-worldness, S, that lack spatial specificity and are insufficient to identify regional brain abnormalities. Here we propose novel ultra-fast methodology for mapping local properties of brain network topology such as local C, L and S (lC, lL and lS) in the human brain at 3-mm isotropic resolution from ‘resting-state’ magnetic resonance imaging data. Test-retest datasets from 40 healthy children/adolescents were used to demonstrate the overall good reliability of the measures across sessions and computational parameters (intraclass correlation > 0.5 for lC and lL) and their low variability across subjects (< 29%). Whereas regions with high local functional connectivity density (lFCD; local degree) in posterior parietal and occipital cortices demonstrated high lC and short lL, subcortical regions (globus pallidus, thalamus, hippocampus and amygdala), cerebellum (lobes and vermis), cingulum and temporal cortex also had high, lS, demonstrating stronger small-world topology than other hubs. Children/adolescents had stronger lFCD, higher lC and longer lL in most cortical regions and thalamus than 74 healthy adults, consistent with pruning of functional connectivity during maturation. In contrast, lFCD, lC and lL were weaker in thalamus and midbrain, and lL was shorter in frontal cortical regions and cerebellum for 69 schizophrenia patients than for 74 healthy controls, suggesting exaggerated pruning of connectivity in schizophrenia. Follow up correlation analyses for seeds in thalamus and midbrain uncovered lower positive connectivity of these regions in thalamus, putamen, cerebellum and frontal cortex (cingulum, orbitofrontal, inferior frontal) and lower negative connectivity in auditory, visual, motor, premotor and somatosensory cortices for schizophrenia patients than for controls, consistent with prior findings of thalamic disconnection in schizophrenia. Public Library of Science 2014-04-30 /pmc/articles/PMC4005771/ /pubmed/24788815 http://dx.doi.org/10.1371/journal.pone.0096176 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
spellingShingle Research Article
Tomasi, Dardo
Volkow, Nora D.
Mapping Small-World Properties through Development in the Human Brain: Disruption in Schizophrenia
title Mapping Small-World Properties through Development in the Human Brain: Disruption in Schizophrenia
title_full Mapping Small-World Properties through Development in the Human Brain: Disruption in Schizophrenia
title_fullStr Mapping Small-World Properties through Development in the Human Brain: Disruption in Schizophrenia
title_full_unstemmed Mapping Small-World Properties through Development in the Human Brain: Disruption in Schizophrenia
title_short Mapping Small-World Properties through Development in the Human Brain: Disruption in Schizophrenia
title_sort mapping small-world properties through development in the human brain: disruption in schizophrenia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005771/
https://www.ncbi.nlm.nih.gov/pubmed/24788815
http://dx.doi.org/10.1371/journal.pone.0096176
work_keys_str_mv AT tomasidardo mappingsmallworldpropertiesthroughdevelopmentinthehumanbraindisruptioninschizophrenia
AT volkownorad mappingsmallworldpropertiesthroughdevelopmentinthehumanbraindisruptioninschizophrenia