Chloride extrusion enhancers as novel therapeutics for neurological diseases

The K(+)-Cl(−) cotransporter KCC2 is responsible for maintaining low Cl(−) concentration in neurons of the central nervous system (CNS), essential for postsynaptic inhibition through GABA(A) and glycine receptors. While no CNS disorders have been associated with KCC2 mutations, loss of activity of t...

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Detalles Bibliográficos
Autores principales: Gagnon, Martin, Bergeron, Marc J., Lavertu, Guillaume, Castonguay, Annie, Tripathy, Sasmita, Bonin, Robert P., Perez-Sanchez, Jimena, Boudreau, Dominic, Wang, Bin, Dumas, Lionel, Valade, Isabelle, Bachand, Karine, Jacob-Wagner, Mariève, Tardif, Christian, Kianicka, Irenej, Isenring, Paul, Attardo, Giorgio, Coull, Jeffrey A.M., De Koninck, Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005788/
https://www.ncbi.nlm.nih.gov/pubmed/24097188
http://dx.doi.org/10.1038/nm.3356

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