Biochemical and functional characterization of Plasmodium falciparum GTP cyclohydrolase I

BACKGROUND: Antifolates are currently in clinical use for malaria preventive therapy and treatment. The drugs kill the parasites by targeting the enzymes in the de novo folate pathway. The use of antifolates has now been limited by the spread of drug-resistant mutations. GTP cyclohydrolase I (GCH1)...

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Detalles Bibliográficos
Autores principales: Kümpornsin, Krittikorn, Kotanan, Namfon, Chobson, Pornpimol, Kochakarn, Theerarat, Jirawatcharadech, Piyaporn, Jaru-ampornpan, Peera, Yuthavong, Yongyuth, Chookajorn, Thanat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005822/
https://www.ncbi.nlm.nih.gov/pubmed/24745605
http://dx.doi.org/10.1186/1475-2875-13-150

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005822/
https://www.ncbi.nlm.nih.gov/pubmed/24745605
http://dx.doi.org/10.1186/1475-2875-13-150

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