Cargando…

Biochemical and functional characterization of Plasmodium falciparum GTP cyclohydrolase I

BACKGROUND: Antifolates are currently in clinical use for malaria preventive therapy and treatment. The drugs kill the parasites by targeting the enzymes in the de novo folate pathway. The use of antifolates has now been limited by the spread of drug-resistant mutations. GTP cyclohydrolase I (GCH1)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kümpornsin, Krittikorn, Kotanan, Namfon, Chobson, Pornpimol, Kochakarn, Theerarat, Jirawatcharadech, Piyaporn, Jaru-ampornpan, Peera, Yuthavong, Yongyuth, Chookajorn, Thanat
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005822/ https://www.ncbi.nlm.nih.gov/pubmed/24745605 http://dx.doi.org/10.1186/1475-2875-13-150

Ejemplares similares

A nuclear targeting system in Plasmodium falciparum
por: Wittayacom, Kanjana, et al.
Publicado: (2010)

The resistome and genomic reconnaissance in the age of malaria elimination
por: Kümpornsin, Krittikorn, et al.
Publicado: (2019)

Fitness Loss under Amino Acid Starvation in Artemisinin-Resistant Plasmodium falciparum Isolates from Cambodia
por: Bunditvorapoom, Duangkamon, et al.
Publicado: (2018)

Overexpression of plasmepsin II and plasmepsin III does not directly cause reduction in Plasmodium falciparum sensitivity to artesunate, chloroquine and piperaquine
por: Loesbanluechai, Duangkamon, et al.
Publicado: (2018)

Genomic surveillance of SARS-CoV-2 in Thailand reveals mixed imported populations, a local lineage expansion and a virus with truncated ORF7a
por: Joonlasak, Khajohn, et al.
Publicado: (2021)

Lumefantrine attenuates Plasmodium falciparum artemisinin resistance during the early ring stage
por: Kümpornsin, Krittikorn, et al.
Publicado: (2021)

Genome-Wide Prediction of the Polymorphic Ser Gene Family in Tetrahymena thermophila Based on Motif Analysis
por: Ponsuwanna, Patrath, et al.
Publicado: (2014)

Comparative genome-wide analysis and evolutionary history of haemoglobin-processing and haem detoxification enzymes in malarial parasites
por: Ponsuwanna, Patrath, et al.
Publicado: (2016)

Pitfalls of exceptions for COVID-19 travel quarantine: lessons from a dignitary visit to Thailand
por: Mungaomklang, Anek, et al.
Publicado: (2021)

COVID-19 Transmission among Healthcare Workers at a Quarantine Facility in Thailand: Genomic and Outbreak Investigations
por: Atsawawaranunt, Kamolthip, et al.
Publicado: (2021)

Generation of a mutator parasite to drive resistome discovery in Plasmodium falciparum
por: Kümpornsin, Krittikorn, et al.
Publicado: (2023)

Amplification of GTP-cyclohydrolase 1 gene in Plasmodium falciparum isolates with the quadruple mutant of dihydrofolate reductase and dihydropteroate synthase genes in Ghana
por: Osei, Musah, et al.
Publicado: (2018)

The Protein Partners of GTP Cyclohydrolase I in Rat Organs
por: Du, Jianhai, et al.
Publicado: (2012)

Parkinson’s disease in GTP cyclohydrolase 1 mutation carriers
por: Mencacci, Niccolò E., et al.
Publicado: (2014)

Selection of drug resistant mutants from random library of Plasmodium falciparum dihydrofolate reductase in Plasmodium berghei model
por: Tipsuwan, Wachiraporn, et al.
Publicado: (2011)

Reply: Parkinson’s disease in GTP cyclohydrolase 1 mutation carriers
por: Mencacci, Niccolo E., et al.
Publicado: (2015)

Combinatorial Genetic Modeling of pfcrt-Mediated Drug Resistance Evolution in Plasmodium falciparum
por: Gabryszewski, Stanislaw J., et al.
Publicado: (2016)

Cardiomyocyte GTP Cyclohydrolase 1 Protects the Heart Against Diabetic Cardiomyopathy
por: Wu, Hsiang-En, et al.
Publicado: (2016)

GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling
por: Kraft, Vanessa A. N., et al.
Publicado: (2019)

A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I
por: Ebenhoch, Rebecca, et al.
Publicado: (2020)

Genetic diversity of the Plasmodium falciparum GTP-cyclohydrolase 1, dihydrofolate reductase and dihydropteroate synthetase genes reveals new insights into sulfadoxine-pyrimethamine antimalarial drug resistance
por: Turkiewicz, Anna, et al.
Publicado: (2020)

Discovery of new non-pyrimidine scaffolds as Plasmodium falciparum DHFR inhibitors by fragment-based screening
por: Hoarau, Marie, et al.
Publicado: (2021)

SARS-CoV-2 RT-PCR positivity of individuals subsequent to completing quarantine upon entry into a country during a transmission-free period
por: Srichatrapimuk, Sirawat, et al.
Publicado: (2022)

Nucleocapsid proteins from other swine enteric coronaviruses differentially modulate PEDV replication
por: Sungsuwan, Suttipun, et al.
Publicado: (2020)

Lack of influence of GTP cyclohydrolase gene (GCH1) variations on pain sensitivity in humans
por: Kim, Hyungsuk, et al.
Publicado: (2007)

Non-Covalent Interaction between Polyubiquitin and GTP Cyclohydrolase 1 Dictates Its Degradation
por: Zhao, Yu, et al.
Publicado: (2012)

Transgenic overexpression of GTP cyclohydrolase 1 in cardiomyocytes ameliorates post-infarction cardiac remodeling
por: Liu, Yanan, et al.
Publicado: (2017)

Elevated GTP Cyclohydrolase I Pathway in Endothelial Progenitor Cells of Overweight Premenopausal Women
por: Wu, Shaohong, et al.
Publicado: (2020)

Identification and Functional Analysis of GTP Cyclohydrolase II in Candida glabrata in Response to Nitrosative Stress
por: Nasuno, Ryo, et al.
Publicado: (2022)

The structure of Plasmodium falciparum serine hydroxymethyltransferase reveals a novel redox switch that regulates its activities
por: Chitnumsub, Penchit, et al.
Publicado: (2014)

Autoimmune Hepatitis Triggered by COVID-19 Vaccine: The First Case From Inactivated Vaccine
por: Mekritthikrai, Krittaya, et al.
Publicado: (2022)

In Vivo Activation of AMP-Activated Protein Kinase Attenuates Diabetes-Enhanced Degradation of GTP Cyclohydrolase I
por: Wang, Shuangxi, et al.
Publicado: (2009)

GTP Cyclohydrolase I and Tyrosine Hydroxylase Gene Mutations in Familial and Sporadic Dopa-Responsive Dystonia Patients
por: Cai, Chunyou, et al.
Publicado: (2013)

Overexpression of GTP Cyclohydrolase 1 Feedback Regulatory Protein Is Protective in a Murine Model of Septic Shock
por: Starr, Anna, et al.
Publicado: (2014)

Structure of GTP cyclohydrolase I from Listeria monocytogenes, a potential anti-infective drug target
por: Schüssler, Sonja, et al.
Publicado: (2019)

Expansion of GTP cyclohydrolase I copy number in malaria parasites resistant to a pyrimidine biosynthesis inhibitor
por: Liu, Shiwei, et al.
Publicado: (2023)

Plasmodium serine hydroxymethyltransferase: indispensability and display of distinct localization
por: Pornthanakasem, Wichai, et al.
Publicado: (2012)

A Genetically Hard-Wired Metabolic Transcriptome in Plasmodium falciparum Fails to Mount Protective Responses to Lethal Antifolates
por: Ganesan, Karthikeyan, et al.
Publicado: (2008)

Scalable synthesis of favipiravir via conventional and continuous flow chemistry
por: Tiyasakulchai, Thanat, et al.
Publicado: (2021)

Does the pain-protective GTP cyclohydrolase haplotype significantly alter the pattern or severity of pain in humans with chronic pancreatitis?
por: Lazarev, Mark, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_2tggmq52r1nif0us8b8elnd8t6