Visualization of cholesterol deposits in lysosomes of Niemann-Pick type C fibroblasts using recombinant perfringolysin O

BACKGROUND: Niemann-Pick disease type C (NPC) is caused by defects in cholesterol efflux from lysosomes due to mutations of genes coding for NPC1 and NPC2 proteins. As a result, massive accumulation of unesterified cholesterol in late endosomes/lysosomes is observed. At the level of the organism the...

Descripción completa

Detalles Bibliográficos
Autores principales: Kwiatkowska, Katarzyna, Marszałek–Sadowska, Ewelina, Traczyk, Gabriela, Koprowski, Piotr, Musielak, Małgorzata, Ługowska, Agnieszka, Kulma, Magdalena, Grzelczyk, Anna, Sobota, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005833/
https://www.ncbi.nlm.nih.gov/pubmed/24775609
http://dx.doi.org/10.1186/1750-1172-9-64

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005833/
https://www.ncbi.nlm.nih.gov/pubmed/24775609
http://dx.doi.org/10.1186/1750-1172-9-64

Ejemplares similares