Renalase, a new secretory enzyme: Its role in hypertensive-ischemic cardiovascular diseases

Renalase, a novel amine oxidase, is mainly expressed in the kidney, heart, and skeletal muscle. It has been known to degrade circulating catecholamines and plays a crucial role in human diseases. Recent studies have demonstrated its structure, unique bioactivities, function, and the gene polymorphis...

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Detalles Bibliográficos
Autores principales: Li, Xiaogang, Huang, Ruixia, Xie, Zijian, Lin, Mingyuan, Liang, Zhongshu, Yang, Yan, Jiang, Weihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2014
Materias:
Review Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005863/
https://www.ncbi.nlm.nih.gov/pubmed/24762661
http://dx.doi.org/10.12659/MSM.890261
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author Li, Xiaogang
Huang, Ruixia
Xie, Zijian
Lin, Mingyuan
Liang, Zhongshu
Yang, Yan
Jiang, Weihong
author_facet Li, Xiaogang
Huang, Ruixia
Xie, Zijian
Lin, Mingyuan
Liang, Zhongshu
Yang, Yan
Jiang, Weihong
author_sort Li, Xiaogang
collection PubMed
description Renalase, a novel amine oxidase, is mainly expressed in the kidney, heart, and skeletal muscle. It has been known to degrade circulating catecholamines and plays a crucial role in human diseases. Recent studies have demonstrated its structure, unique bioactivities, function, and the gene polymorphisms in human diseases. In this review, we summarize the effects of renalase on hypertension, myocardial ischemia, acute kidney injury (AKI), ischemic stroke, cardiac dysfunction, organ transplantation, and diabetes mellitus reported in numerous studies.
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spelling pubmed-40058632014-05-01 Renalase, a new secretory enzyme: Its role in hypertensive-ischemic cardiovascular diseases Li, Xiaogang Huang, Ruixia Xie, Zijian Lin, Mingyuan Liang, Zhongshu Yang, Yan Jiang, Weihong Med Sci Monit Review Articles Renalase, a novel amine oxidase, is mainly expressed in the kidney, heart, and skeletal muscle. It has been known to degrade circulating catecholamines and plays a crucial role in human diseases. Recent studies have demonstrated its structure, unique bioactivities, function, and the gene polymorphisms in human diseases. In this review, we summarize the effects of renalase on hypertension, myocardial ischemia, acute kidney injury (AKI), ischemic stroke, cardiac dysfunction, organ transplantation, and diabetes mellitus reported in numerous studies. International Scientific Literature, Inc. 2014-04-25 /pmc/articles/PMC4005863/ /pubmed/24762661 http://dx.doi.org/10.12659/MSM.890261 Text en © Med Sci Monit, 2014 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License
spellingShingle Review Articles
Li, Xiaogang
Huang, Ruixia
Xie, Zijian
Lin, Mingyuan
Liang, Zhongshu
Yang, Yan
Jiang, Weihong
Renalase, a new secretory enzyme: Its role in hypertensive-ischemic cardiovascular diseases
title Renalase, a new secretory enzyme: Its role in hypertensive-ischemic cardiovascular diseases
title_full Renalase, a new secretory enzyme: Its role in hypertensive-ischemic cardiovascular diseases
title_fullStr Renalase, a new secretory enzyme: Its role in hypertensive-ischemic cardiovascular diseases
title_full_unstemmed Renalase, a new secretory enzyme: Its role in hypertensive-ischemic cardiovascular diseases
title_short Renalase, a new secretory enzyme: Its role in hypertensive-ischemic cardiovascular diseases
title_sort renalase, a new secretory enzyme: its role in hypertensive-ischemic cardiovascular diseases
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005863/
https://www.ncbi.nlm.nih.gov/pubmed/24762661
http://dx.doi.org/10.12659/MSM.890261
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