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Cyclic-AMP and bacterial cyclic-AMP receptor proteins revisited: adaptation for different ecological niches()
Escherichia coli cyclic-AMP receptor protein (CRP) represents one of the paradigms of bacterial gene regulation. Yet despite decades of intensive study, new information continues to emerge that prompts reassessment of this classic regulatory system. Moreover, in recent years CRPs from several other...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Current Biology
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005916/ https://www.ncbi.nlm.nih.gov/pubmed/24509484 http://dx.doi.org/10.1016/j.mib.2014.01.003 |
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author | Green, Jeffrey Stapleton, Melanie R Smith, Laura J Artymiuk, Peter J Kahramanoglou, Christina Hunt, Debbie M Buxton, Roger S |
author_facet | Green, Jeffrey Stapleton, Melanie R Smith, Laura J Artymiuk, Peter J Kahramanoglou, Christina Hunt, Debbie M Buxton, Roger S |
author_sort | Green, Jeffrey |
collection | PubMed |
description | Escherichia coli cyclic-AMP receptor protein (CRP) represents one of the paradigms of bacterial gene regulation. Yet despite decades of intensive study, new information continues to emerge that prompts reassessment of this classic regulatory system. Moreover, in recent years CRPs from several other bacterial species have been characterized, allowing the general applicability of the CRP paradigm to be tested. Here the properties of the E. coli, Mycobacterium tuberculosis and Pseudomonas putida CRPs are considered in the context of the ecological niches occupied by these bacteria. It appears that the cyclic-AMP-CRP regulatory system has been adapted to respond to distinct external and internal inputs across a broad sensitivity range that is, at least in part, determined by bacterial lifestyles. |
format | Online Article Text |
id | pubmed-4005916 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Current Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-40059162014-05-02 Cyclic-AMP and bacterial cyclic-AMP receptor proteins revisited: adaptation for different ecological niches() Green, Jeffrey Stapleton, Melanie R Smith, Laura J Artymiuk, Peter J Kahramanoglou, Christina Hunt, Debbie M Buxton, Roger S Curr Opin Microbiol Article Escherichia coli cyclic-AMP receptor protein (CRP) represents one of the paradigms of bacterial gene regulation. Yet despite decades of intensive study, new information continues to emerge that prompts reassessment of this classic regulatory system. Moreover, in recent years CRPs from several other bacterial species have been characterized, allowing the general applicability of the CRP paradigm to be tested. Here the properties of the E. coli, Mycobacterium tuberculosis and Pseudomonas putida CRPs are considered in the context of the ecological niches occupied by these bacteria. It appears that the cyclic-AMP-CRP regulatory system has been adapted to respond to distinct external and internal inputs across a broad sensitivity range that is, at least in part, determined by bacterial lifestyles. Current Biology 2014-04 /pmc/articles/PMC4005916/ /pubmed/24509484 http://dx.doi.org/10.1016/j.mib.2014.01.003 Text en © 2014 The Authors http://creativecommons.org/licenses/by/3.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Green, Jeffrey Stapleton, Melanie R Smith, Laura J Artymiuk, Peter J Kahramanoglou, Christina Hunt, Debbie M Buxton, Roger S Cyclic-AMP and bacterial cyclic-AMP receptor proteins revisited: adaptation for different ecological niches() |
title | Cyclic-AMP and bacterial cyclic-AMP receptor proteins revisited: adaptation for different ecological niches() |
title_full | Cyclic-AMP and bacterial cyclic-AMP receptor proteins revisited: adaptation for different ecological niches() |
title_fullStr | Cyclic-AMP and bacterial cyclic-AMP receptor proteins revisited: adaptation for different ecological niches() |
title_full_unstemmed | Cyclic-AMP and bacterial cyclic-AMP receptor proteins revisited: adaptation for different ecological niches() |
title_short | Cyclic-AMP and bacterial cyclic-AMP receptor proteins revisited: adaptation for different ecological niches() |
title_sort | cyclic-amp and bacterial cyclic-amp receptor proteins revisited: adaptation for different ecological niches() |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005916/ https://www.ncbi.nlm.nih.gov/pubmed/24509484 http://dx.doi.org/10.1016/j.mib.2014.01.003 |
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