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miR-191: an emerging player in disease biology
Specific microRNAs have emerged as key players in disease biology by playing crucial role in disease development and progression. This review draws attention to one such microRNA, miR-191 that has been recently reported to be abnormally expressed in several cancers (>20) and various other disease...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005961/ https://www.ncbi.nlm.nih.gov/pubmed/24795757 http://dx.doi.org/10.3389/fgene.2014.00099 |
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author | Nagpal, Neha Kulshreshtha, Ritu |
author_facet | Nagpal, Neha Kulshreshtha, Ritu |
author_sort | Nagpal, Neha |
collection | PubMed |
description | Specific microRNAs have emerged as key players in disease biology by playing crucial role in disease development and progression. This review draws attention to one such microRNA, miR-191 that has been recently reported to be abnormally expressed in several cancers (>20) and various other diseases like diabetes-type 2, Crohn’ s, pulmonary hypertension, and Alzheimer’ s. It regulates important cellular processes such as cell proliferation, differentiation, apoptosis, and migration by targeting important transcription factors, chromatin remodelers, and cell cycle associated genes. Several studies have demonstrated it to be an excellent biomarker for cancer diagnosis and prognosis leading to two patents already in its kitty. In this first review we summarize the current knowledge of the regulation, functions and targets of miR-191 and discuss its potential as a promising disease biomarker and therapeutic target. |
format | Online Article Text |
id | pubmed-4005961 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-40059612014-05-02 miR-191: an emerging player in disease biology Nagpal, Neha Kulshreshtha, Ritu Front Genet Genetics Specific microRNAs have emerged as key players in disease biology by playing crucial role in disease development and progression. This review draws attention to one such microRNA, miR-191 that has been recently reported to be abnormally expressed in several cancers (>20) and various other diseases like diabetes-type 2, Crohn’ s, pulmonary hypertension, and Alzheimer’ s. It regulates important cellular processes such as cell proliferation, differentiation, apoptosis, and migration by targeting important transcription factors, chromatin remodelers, and cell cycle associated genes. Several studies have demonstrated it to be an excellent biomarker for cancer diagnosis and prognosis leading to two patents already in its kitty. In this first review we summarize the current knowledge of the regulation, functions and targets of miR-191 and discuss its potential as a promising disease biomarker and therapeutic target. Frontiers Media S.A. 2014-04-23 /pmc/articles/PMC4005961/ /pubmed/24795757 http://dx.doi.org/10.3389/fgene.2014.00099 Text en Copyright © 2014 Nagpal and Kulshreshtha. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Nagpal, Neha Kulshreshtha, Ritu miR-191: an emerging player in disease biology |
title | miR-191: an emerging player in disease biology |
title_full | miR-191: an emerging player in disease biology |
title_fullStr | miR-191: an emerging player in disease biology |
title_full_unstemmed | miR-191: an emerging player in disease biology |
title_short | miR-191: an emerging player in disease biology |
title_sort | mir-191: an emerging player in disease biology |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005961/ https://www.ncbi.nlm.nih.gov/pubmed/24795757 http://dx.doi.org/10.3389/fgene.2014.00099 |
work_keys_str_mv | AT nagpalneha mir191anemergingplayerindiseasebiology AT kulshreshtharitu mir191anemergingplayerindiseasebiology |