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Physical activity reduces hippocampal atrophy in elders at genetic risk for Alzheimer's disease

We examined the impact of physical activity (PA) on longitudinal change in hippocampal volume in cognitively intact older adults at varying genetic risk for the sporadic form of Alzheimer's disease (AD). Hippocampal volume was measured from structural magnetic resonance imaging (MRI) scans admi...

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Autores principales: Smith, J. Carson, Nielson, Kristy A., Woodard, John L., Seidenberg, Michael, Durgerian, Sally, Hazlett, Kathleen E., Figueroa, Christina M., Kandah, Cassandra C., Kay, Christina D., Matthews, Monica A., Rao, Stephen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005962/
https://www.ncbi.nlm.nih.gov/pubmed/24795624
http://dx.doi.org/10.3389/fnagi.2014.00061
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author Smith, J. Carson
Nielson, Kristy A.
Woodard, John L.
Seidenberg, Michael
Durgerian, Sally
Hazlett, Kathleen E.
Figueroa, Christina M.
Kandah, Cassandra C.
Kay, Christina D.
Matthews, Monica A.
Rao, Stephen M.
author_facet Smith, J. Carson
Nielson, Kristy A.
Woodard, John L.
Seidenberg, Michael
Durgerian, Sally
Hazlett, Kathleen E.
Figueroa, Christina M.
Kandah, Cassandra C.
Kay, Christina D.
Matthews, Monica A.
Rao, Stephen M.
author_sort Smith, J. Carson
collection PubMed
description We examined the impact of physical activity (PA) on longitudinal change in hippocampal volume in cognitively intact older adults at varying genetic risk for the sporadic form of Alzheimer's disease (AD). Hippocampal volume was measured from structural magnetic resonance imaging (MRI) scans administered at baseline and at an 18-month follow-up in 97 healthy, cognitively intact older adults. Participants were classified as High or Low PA based on a self-report questionnaire of frequency and intensity of exercise. Risk status was defined by the presence or absence of the apolipoprotein E-epsilon 4 (APOE-ε4) allele. Four subgroups were studied: Low Risk/High PA (n = 24), Low Risk/Low PA (n = 34), High Risk/High PA (n = 22), and High Risk/Low PA (n = 17). Over the 18 month follow-up interval, hippocampal volume decreased by 3% in the High Risk/Low PA group, but remained stable in the three remaining groups. No main effects or interactions between genetic risk and PA were observed in control brain regions, including the caudate, amygdala, thalamus, pre-central gyrus, caudal middle frontal gyrus, cortical white matter (WM), and total gray matter (GM). These findings suggest that PA may help to preserve hippocampal volume in individuals at increased genetic risk for AD. The protective effects of PA on hippocampal atrophy were not observed in individuals at low risk for AD. These data suggest that individuals at genetic risk for AD should be targeted for increased levels of PA as a means of reducing atrophy in a brain region critical for the formation of episodic memories.
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spelling pubmed-40059622014-05-02 Physical activity reduces hippocampal atrophy in elders at genetic risk for Alzheimer's disease Smith, J. Carson Nielson, Kristy A. Woodard, John L. Seidenberg, Michael Durgerian, Sally Hazlett, Kathleen E. Figueroa, Christina M. Kandah, Cassandra C. Kay, Christina D. Matthews, Monica A. Rao, Stephen M. Front Aging Neurosci Neuroscience We examined the impact of physical activity (PA) on longitudinal change in hippocampal volume in cognitively intact older adults at varying genetic risk for the sporadic form of Alzheimer's disease (AD). Hippocampal volume was measured from structural magnetic resonance imaging (MRI) scans administered at baseline and at an 18-month follow-up in 97 healthy, cognitively intact older adults. Participants were classified as High or Low PA based on a self-report questionnaire of frequency and intensity of exercise. Risk status was defined by the presence or absence of the apolipoprotein E-epsilon 4 (APOE-ε4) allele. Four subgroups were studied: Low Risk/High PA (n = 24), Low Risk/Low PA (n = 34), High Risk/High PA (n = 22), and High Risk/Low PA (n = 17). Over the 18 month follow-up interval, hippocampal volume decreased by 3% in the High Risk/Low PA group, but remained stable in the three remaining groups. No main effects or interactions between genetic risk and PA were observed in control brain regions, including the caudate, amygdala, thalamus, pre-central gyrus, caudal middle frontal gyrus, cortical white matter (WM), and total gray matter (GM). These findings suggest that PA may help to preserve hippocampal volume in individuals at increased genetic risk for AD. The protective effects of PA on hippocampal atrophy were not observed in individuals at low risk for AD. These data suggest that individuals at genetic risk for AD should be targeted for increased levels of PA as a means of reducing atrophy in a brain region critical for the formation of episodic memories. Frontiers Media S.A. 2014-04-23 /pmc/articles/PMC4005962/ /pubmed/24795624 http://dx.doi.org/10.3389/fnagi.2014.00061 Text en Copyright © 2014 Smith, Nielson, Woodard, Seidenberg, Durgerian, Hazlett, Figueroa, Kandah, Kay, Matthews and Rao. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Smith, J. Carson
Nielson, Kristy A.
Woodard, John L.
Seidenberg, Michael
Durgerian, Sally
Hazlett, Kathleen E.
Figueroa, Christina M.
Kandah, Cassandra C.
Kay, Christina D.
Matthews, Monica A.
Rao, Stephen M.
Physical activity reduces hippocampal atrophy in elders at genetic risk for Alzheimer's disease
title Physical activity reduces hippocampal atrophy in elders at genetic risk for Alzheimer's disease
title_full Physical activity reduces hippocampal atrophy in elders at genetic risk for Alzheimer's disease
title_fullStr Physical activity reduces hippocampal atrophy in elders at genetic risk for Alzheimer's disease
title_full_unstemmed Physical activity reduces hippocampal atrophy in elders at genetic risk for Alzheimer's disease
title_short Physical activity reduces hippocampal atrophy in elders at genetic risk for Alzheimer's disease
title_sort physical activity reduces hippocampal atrophy in elders at genetic risk for alzheimer's disease
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005962/
https://www.ncbi.nlm.nih.gov/pubmed/24795624
http://dx.doi.org/10.3389/fnagi.2014.00061
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