Cargando…
Efficacy of Different Protocols of Radioiodine Therapy for Treatment of Toxic Nodular Goiter: Systematic Review and Meta-Analysis of the Literature
CONTEXT: To evaluate treatment success and hypothyroidism following main methods of radioiodine therapy of toxic nodular goiter (TNG); calculated versus fixed dose and high versus low dose of radioiodine. EVIDENCE ACQUISITIONS: We searched MEDLINE and SCOPUS databases from inception till July 2013,...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Kowsar
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005974/ https://www.ncbi.nlm.nih.gov/pubmed/24803943 http://dx.doi.org/10.5812/ijem.14424 |
_version_ | 1782314177998618624 |
---|---|
author | Rokni, Haleh Sadeghi, Ramin Moossavi, Zohreh Treglia, Giorgio Zakavi, Seyed Rasoul |
author_facet | Rokni, Haleh Sadeghi, Ramin Moossavi, Zohreh Treglia, Giorgio Zakavi, Seyed Rasoul |
author_sort | Rokni, Haleh |
collection | PubMed |
description | CONTEXT: To evaluate treatment success and hypothyroidism following main methods of radioiodine therapy of toxic nodular goiter (TNG); calculated versus fixed dose and high versus low dose of radioiodine. EVIDENCE ACQUISITIONS: We searched MEDLINE and SCOPUS databases from inception till July 2013, for clinical trials that compared two different methods of radioiodine administration in TNG. The trials were classified into two groups, those that compared fixed versus calculated dosimetry method and those that assessed high fixed dose versus low fixed dose method. Treatment response was defined as euthyroidism or hypothyroidism, one year after radioiodine administration. We calculated the risk ratio and risk difference of treatment response as well as permanent hypothyroidism as outcome variables. Random effects model was used for data pooling. RESULTS: The literature search yielded 2538 articles. Two randomized and five non-randomized clinical trials with 669 patients met the eligibility criteria for the meta-analysis. Patients with TNG who were treated according to the calculated method had 9.6% higher cure rate (risk ratio=1.17) and only 0.3% more permanent hypothyroidism compared to patients treated with the fixed dose method. There was no significant difference in the amount of administered radio-iodine in the two groups. Patients treated with fixed high dose had 18.1% more cure rate (risk ratio = 1.2) and 23.9% more permanent hypothyroidism (risk ratio = 2.40) compared to patients treated by fixed low dose protocols. CONCLUSIONS: Calculated radioiodine therapy may be preferred to fixed dose method in patients with TNG. High dose methods are associated with more response and more hypothyroidism. |
format | Online Article Text |
id | pubmed-4005974 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Kowsar |
record_format | MEDLINE/PubMed |
spelling | pubmed-40059742014-05-06 Efficacy of Different Protocols of Radioiodine Therapy for Treatment of Toxic Nodular Goiter: Systematic Review and Meta-Analysis of the Literature Rokni, Haleh Sadeghi, Ramin Moossavi, Zohreh Treglia, Giorgio Zakavi, Seyed Rasoul Int J Endocrinol Metab Review Article CONTEXT: To evaluate treatment success and hypothyroidism following main methods of radioiodine therapy of toxic nodular goiter (TNG); calculated versus fixed dose and high versus low dose of radioiodine. EVIDENCE ACQUISITIONS: We searched MEDLINE and SCOPUS databases from inception till July 2013, for clinical trials that compared two different methods of radioiodine administration in TNG. The trials were classified into two groups, those that compared fixed versus calculated dosimetry method and those that assessed high fixed dose versus low fixed dose method. Treatment response was defined as euthyroidism or hypothyroidism, one year after radioiodine administration. We calculated the risk ratio and risk difference of treatment response as well as permanent hypothyroidism as outcome variables. Random effects model was used for data pooling. RESULTS: The literature search yielded 2538 articles. Two randomized and five non-randomized clinical trials with 669 patients met the eligibility criteria for the meta-analysis. Patients with TNG who were treated according to the calculated method had 9.6% higher cure rate (risk ratio=1.17) and only 0.3% more permanent hypothyroidism compared to patients treated with the fixed dose method. There was no significant difference in the amount of administered radio-iodine in the two groups. Patients treated with fixed high dose had 18.1% more cure rate (risk ratio = 1.2) and 23.9% more permanent hypothyroidism (risk ratio = 2.40) compared to patients treated by fixed low dose protocols. CONCLUSIONS: Calculated radioiodine therapy may be preferred to fixed dose method in patients with TNG. High dose methods are associated with more response and more hypothyroidism. Kowsar 2014-04-01 /pmc/articles/PMC4005974/ /pubmed/24803943 http://dx.doi.org/10.5812/ijem.14424 Text en Copyright © 2014, Research Institute For Endocrine Sciences and Iran Endocrine Society; Published by Kowsar Corp. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Rokni, Haleh Sadeghi, Ramin Moossavi, Zohreh Treglia, Giorgio Zakavi, Seyed Rasoul Efficacy of Different Protocols of Radioiodine Therapy for Treatment of Toxic Nodular Goiter: Systematic Review and Meta-Analysis of the Literature |
title | Efficacy of Different Protocols of Radioiodine Therapy for Treatment of Toxic Nodular Goiter: Systematic Review and Meta-Analysis of the Literature |
title_full | Efficacy of Different Protocols of Radioiodine Therapy for Treatment of Toxic Nodular Goiter: Systematic Review and Meta-Analysis of the Literature |
title_fullStr | Efficacy of Different Protocols of Radioiodine Therapy for Treatment of Toxic Nodular Goiter: Systematic Review and Meta-Analysis of the Literature |
title_full_unstemmed | Efficacy of Different Protocols of Radioiodine Therapy for Treatment of Toxic Nodular Goiter: Systematic Review and Meta-Analysis of the Literature |
title_short | Efficacy of Different Protocols of Radioiodine Therapy for Treatment of Toxic Nodular Goiter: Systematic Review and Meta-Analysis of the Literature |
title_sort | efficacy of different protocols of radioiodine therapy for treatment of toxic nodular goiter: systematic review and meta-analysis of the literature |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005974/ https://www.ncbi.nlm.nih.gov/pubmed/24803943 http://dx.doi.org/10.5812/ijem.14424 |
work_keys_str_mv | AT roknihaleh efficacyofdifferentprotocolsofradioiodinetherapyfortreatmentoftoxicnodulargoitersystematicreviewandmetaanalysisoftheliterature AT sadeghiramin efficacyofdifferentprotocolsofradioiodinetherapyfortreatmentoftoxicnodulargoitersystematicreviewandmetaanalysisoftheliterature AT moossavizohreh efficacyofdifferentprotocolsofradioiodinetherapyfortreatmentoftoxicnodulargoitersystematicreviewandmetaanalysisoftheliterature AT tregliagiorgio efficacyofdifferentprotocolsofradioiodinetherapyfortreatmentoftoxicnodulargoitersystematicreviewandmetaanalysisoftheliterature AT zakaviseyedrasoul efficacyofdifferentprotocolsofradioiodinetherapyfortreatmentoftoxicnodulargoitersystematicreviewandmetaanalysisoftheliterature |