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Bright Building Blocks for Chemical Biology
[Image: see text] Small-molecule fluorophores manifest the ability of chemistry to solve problems in biology. As we noted in a previous review (Lavis, L. D.; Raines, R. T. ACS Chem. Biol.2008, 3, 142–155), the extant collection of fluorescent probes is built on a modest set of “core” scaffolds that...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American
Chemical
Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006396/ https://www.ncbi.nlm.nih.gov/pubmed/24579725 http://dx.doi.org/10.1021/cb500078u |
| _version_ | 1782314213304172544 |
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| author | Lavis, Luke D. Raines, Ronald T. |
| author_facet | Lavis, Luke D. Raines, Ronald T. |
| author_sort | Lavis, Luke D. |
| collection | PubMed |
| description | [Image: see text] Small-molecule fluorophores manifest the ability of chemistry to solve problems in biology. As we noted in a previous review (Lavis, L. D.; Raines, R. T. ACS Chem. Biol.2008, 3, 142–155), the extant collection of fluorescent probes is built on a modest set of “core” scaffolds that evolved during a century of academic and industrial research. Here, we survey traditional and modern synthetic routes to small-molecule fluorophores and highlight recent biological insights attained with customized fluorescent probes. Our intent is to inspire the design and creation of new high-precision tools that empower chemical biologists. |
| format | Online Article Text |
| id | pubmed-4006396 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2014 |
| publisher | American
Chemical
Society |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-40063962014-05-01 Bright Building Blocks for Chemical Biology Lavis, Luke D. Raines, Ronald T. ACS Chem Biol [Image: see text] Small-molecule fluorophores manifest the ability of chemistry to solve problems in biology. As we noted in a previous review (Lavis, L. D.; Raines, R. T. ACS Chem. Biol.2008, 3, 142–155), the extant collection of fluorescent probes is built on a modest set of “core” scaffolds that evolved during a century of academic and industrial research. Here, we survey traditional and modern synthetic routes to small-molecule fluorophores and highlight recent biological insights attained with customized fluorescent probes. Our intent is to inspire the design and creation of new high-precision tools that empower chemical biologists. American Chemical Society 2014-02-28 2014-04-18 /pmc/articles/PMC4006396/ /pubmed/24579725 http://dx.doi.org/10.1021/cb500078u Text en Copyright © 2014 American Chemical Society Terms of Use (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) |
| spellingShingle | Lavis, Luke D. Raines, Ronald T. Bright Building Blocks for Chemical Biology |
| title | Bright Building Blocks for Chemical Biology |
| title_full | Bright Building Blocks for Chemical Biology |
| title_fullStr | Bright Building Blocks for Chemical Biology |
| title_full_unstemmed | Bright Building Blocks for Chemical Biology |
| title_short | Bright Building Blocks for Chemical Biology |
| title_sort | bright building blocks for chemical biology |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006396/ https://www.ncbi.nlm.nih.gov/pubmed/24579725 http://dx.doi.org/10.1021/cb500078u |
| work_keys_str_mv | AT lavisluked brightbuildingblocksforchemicalbiology AT rainesronaldt brightbuildingblocksforchemicalbiology |