An omnibus permutation test on ensembles of two-locus analyses can detect pure epistasis and genetic heterogeneity in genome-wide association studies

This article presents the ability of an omnibus permutation test on ensembles of two-locus analyses (2LOmb) to detect pure epistasis in the presence of genetic heterogeneity. The performance of 2LOmb is evaluated in various simulation scenarios covering two independent causes of complex disease wher...

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Detalles Bibliográficos
Autores principales: Setsirichok, Damrongrit, Tienboon, Phuwadej, Jaroonruang, Nattapong, Kittichaijaroen, Somkit, Wongseree, Waranyu, Piroonratana, Theera, Usavanarong, Touchpong, Limwongse, Chanin, Aporntewan, Chatchawit, Phadoongsidhi, Marong, Chaiyaratana, Nachol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006521/
https://www.ncbi.nlm.nih.gov/pubmed/24804170
http://dx.doi.org/10.1186/2193-1801-2-230

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