Transforming growth factor-β induces Cdk2 relocalization to the cytoplasm coincident with dephosphorylation of retinoblastoma tumor suppressor protein

BACKGROUND: The transforming growth factor-β (TGF-β) signaling pathway functions to prevent tumorigenesis, and loss of sensitivity to TGF-β-mediated cell cycle arrest is nearly ubiquitous among human cancers. Our previous studies demonstrated that rapamycin potentiates TGF-β-induced cell cycle arres...

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Detalles Bibliográficos
Autores principales: Brown, Kimberly A, Roberts, Richard L, Arteaga, Carlos L, Law, Brian K
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC400660/
https://www.ncbi.nlm.nih.gov/pubmed/14979923

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