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Infiltrating lobular carcinoma of the breast: tumor characteristics and clinical outcome

INTRODUCTION: Invasive lobular carcinoma (ILC) comprises approximately 10% of breast cancers and appears to have a distinct biology. Because it is less common than infiltrating ductal carcinoma (IDC), few data have been reported that address the biologic features of ILC in the context of their clini...

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Autores principales: Arpino, Grazia, Bardou, Valerie J, Clark, Gary M, Elledge, Richard M
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC400666/
https://www.ncbi.nlm.nih.gov/pubmed/15084238
http://dx.doi.org/10.1186/bcr767
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author Arpino, Grazia
Bardou, Valerie J
Clark, Gary M
Elledge, Richard M
author_facet Arpino, Grazia
Bardou, Valerie J
Clark, Gary M
Elledge, Richard M
author_sort Arpino, Grazia
collection PubMed
description INTRODUCTION: Invasive lobular carcinoma (ILC) comprises approximately 10% of breast cancers and appears to have a distinct biology. Because it is less common than infiltrating ductal carcinoma (IDC), few data have been reported that address the biologic features of ILC in the context of their clinical outcome. In the present study we undertook an extensive comparison of ILC and IDC using a large database to provide a more complete and reliable assessment of their biologic phenotypes and clinical behaviors. METHODS: The clinical and biological features of 4140 patients with ILC were compared with those of 45,169 patients with IDC (not otherwise specified). The median follow-up period was 87 months. RESULTS: In comparison with IDC, ILC was significantly more likely to occur in older patients, to be larger in size, to be estrogen and progesterone receptor positive, to have lower S-phase fraction, to be diploid, and to be HER-2, p53, and epidermal growth factor receptor negative. It was more common for ILC than for IDC to metastasize to the gastrointestinal tract and ovary. The incidence of contralateral breast cancer was higher for ILC patients than for IDC patients (20.9% versus 11.2%; P < 0.0001). Breast preservation was modestly less frequent in ILC patients than in IDC patients. The 5-year disease-free survival was 85.7% for ILC and 83.5% for IDC (P = 0.13). The 5-year overall survival was 85.6% for ILC and 84.1% for IDC (P = 0.64). CONCLUSION: Despite the fact that the biologic phenotype of ILC is quite favorable, these patients do not have better clinical outcomes than do patients with IDC. At present, management decisions should be based on individual patient and tumor biologic characteristics, and not on lobular histology.
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spelling pubmed-4006662004-05-01 Infiltrating lobular carcinoma of the breast: tumor characteristics and clinical outcome Arpino, Grazia Bardou, Valerie J Clark, Gary M Elledge, Richard M Breast Cancer Res Research Article INTRODUCTION: Invasive lobular carcinoma (ILC) comprises approximately 10% of breast cancers and appears to have a distinct biology. Because it is less common than infiltrating ductal carcinoma (IDC), few data have been reported that address the biologic features of ILC in the context of their clinical outcome. In the present study we undertook an extensive comparison of ILC and IDC using a large database to provide a more complete and reliable assessment of their biologic phenotypes and clinical behaviors. METHODS: The clinical and biological features of 4140 patients with ILC were compared with those of 45,169 patients with IDC (not otherwise specified). The median follow-up period was 87 months. RESULTS: In comparison with IDC, ILC was significantly more likely to occur in older patients, to be larger in size, to be estrogen and progesterone receptor positive, to have lower S-phase fraction, to be diploid, and to be HER-2, p53, and epidermal growth factor receptor negative. It was more common for ILC than for IDC to metastasize to the gastrointestinal tract and ovary. The incidence of contralateral breast cancer was higher for ILC patients than for IDC patients (20.9% versus 11.2%; P < 0.0001). Breast preservation was modestly less frequent in ILC patients than in IDC patients. The 5-year disease-free survival was 85.7% for ILC and 83.5% for IDC (P = 0.13). The 5-year overall survival was 85.6% for ILC and 84.1% for IDC (P = 0.64). CONCLUSION: Despite the fact that the biologic phenotype of ILC is quite favorable, these patients do not have better clinical outcomes than do patients with IDC. At present, management decisions should be based on individual patient and tumor biologic characteristics, and not on lobular histology. BioMed Central 2004 2004-02-17 /pmc/articles/PMC400666/ /pubmed/15084238 http://dx.doi.org/10.1186/bcr767 Text en Copyright © 2004 Arpino et al., licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
spellingShingle Research Article
Arpino, Grazia
Bardou, Valerie J
Clark, Gary M
Elledge, Richard M
Infiltrating lobular carcinoma of the breast: tumor characteristics and clinical outcome
title Infiltrating lobular carcinoma of the breast: tumor characteristics and clinical outcome
title_full Infiltrating lobular carcinoma of the breast: tumor characteristics and clinical outcome
title_fullStr Infiltrating lobular carcinoma of the breast: tumor characteristics and clinical outcome
title_full_unstemmed Infiltrating lobular carcinoma of the breast: tumor characteristics and clinical outcome
title_short Infiltrating lobular carcinoma of the breast: tumor characteristics and clinical outcome
title_sort infiltrating lobular carcinoma of the breast: tumor characteristics and clinical outcome
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC400666/
https://www.ncbi.nlm.nih.gov/pubmed/15084238
http://dx.doi.org/10.1186/bcr767
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