R-loops Associated with Triplet Repeat Expansions Promote Gene Silencing in Friedreich Ataxia and Fragile X Syndrome

Friedreich ataxia (FRDA) and Fragile X syndrome (FXS) are among 40 diseases associated with expansion of repeated sequences (TREDs). Although their molecular pathology is not well understood, formation of repressive chromatin and unusual DNA structures over repeat regions were proposed to play a rol...

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Detalles Bibliográficos
Autores principales: Groh, Matthias, Lufino, Michele M. P., Wade-Martins, Richard, Gromak, Natalia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006715/
https://www.ncbi.nlm.nih.gov/pubmed/24787137
http://dx.doi.org/10.1371/journal.pgen.1004318

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