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Heritable Transmission of Stress Resistance by High Dietary Glucose in Caenorhabditis elegans

Glucose is a major energy source and is a key regulator of metabolism but excessive dietary glucose is linked to several disorders including type 2 diabetes, obesity and cardiac dysfunction. Dietary intake greatly influences organismal survival but whether the effects of nutritional status are trans...

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Autores principales: Tauffenberger, Arnaud, Parker, J. Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006733/
https://www.ncbi.nlm.nih.gov/pubmed/24785260
http://dx.doi.org/10.1371/journal.pgen.1004346
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author Tauffenberger, Arnaud
Parker, J. Alex
author_facet Tauffenberger, Arnaud
Parker, J. Alex
author_sort Tauffenberger, Arnaud
collection PubMed
description Glucose is a major energy source and is a key regulator of metabolism but excessive dietary glucose is linked to several disorders including type 2 diabetes, obesity and cardiac dysfunction. Dietary intake greatly influences organismal survival but whether the effects of nutritional status are transmitted to the offspring is an unresolved question. Here we show that exposing Caenorhabditis elegans to high glucose concentrations in the parental generation leads to opposing negative effects on fecundity, while having protective effects against cellular stress in the descendent progeny. The transgenerational inheritance of glucose-mediated phenotypes is dependent on the insulin/IGF-like signalling pathway and components of the histone H3 lysine 4 trimethylase complex are essential for transmission of inherited phenotypes. Thus dietary over-consumption phenotypes are heritable with profound effects on the health and survival of descendants.
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spelling pubmed-40067332014-05-09 Heritable Transmission of Stress Resistance by High Dietary Glucose in Caenorhabditis elegans Tauffenberger, Arnaud Parker, J. Alex PLoS Genet Research Article Glucose is a major energy source and is a key regulator of metabolism but excessive dietary glucose is linked to several disorders including type 2 diabetes, obesity and cardiac dysfunction. Dietary intake greatly influences organismal survival but whether the effects of nutritional status are transmitted to the offspring is an unresolved question. Here we show that exposing Caenorhabditis elegans to high glucose concentrations in the parental generation leads to opposing negative effects on fecundity, while having protective effects against cellular stress in the descendent progeny. The transgenerational inheritance of glucose-mediated phenotypes is dependent on the insulin/IGF-like signalling pathway and components of the histone H3 lysine 4 trimethylase complex are essential for transmission of inherited phenotypes. Thus dietary over-consumption phenotypes are heritable with profound effects on the health and survival of descendants. Public Library of Science 2014-05-01 /pmc/articles/PMC4006733/ /pubmed/24785260 http://dx.doi.org/10.1371/journal.pgen.1004346 Text en © 2014 Tauffenberger, Parker http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Tauffenberger, Arnaud
Parker, J. Alex
Heritable Transmission of Stress Resistance by High Dietary Glucose in Caenorhabditis elegans
title Heritable Transmission of Stress Resistance by High Dietary Glucose in Caenorhabditis elegans
title_full Heritable Transmission of Stress Resistance by High Dietary Glucose in Caenorhabditis elegans
title_fullStr Heritable Transmission of Stress Resistance by High Dietary Glucose in Caenorhabditis elegans
title_full_unstemmed Heritable Transmission of Stress Resistance by High Dietary Glucose in Caenorhabditis elegans
title_short Heritable Transmission of Stress Resistance by High Dietary Glucose in Caenorhabditis elegans
title_sort heritable transmission of stress resistance by high dietary glucose in caenorhabditis elegans
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006733/
https://www.ncbi.nlm.nih.gov/pubmed/24785260
http://dx.doi.org/10.1371/journal.pgen.1004346
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