Lifespan Extension by Methionine Restriction Requires Autophagy-Dependent Vacuolar Acidification

Reduced supply of the amino acid methionine increases longevity across species through an as yet elusive mechanism. Here, we report that methionine restriction (MetR) extends yeast chronological lifespan in an autophagy-dependent manner. Single deletion of several genes essential for autophagy (ATG5...

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Detalles Bibliográficos
Autores principales: Ruckenstuhl, Christoph, Netzberger, Christine, Entfellner, Iryna, Carmona-Gutierrez, Didac, Kickenweiz, Thomas, Stekovic, Slaven, Gleixner, Christina, Schmid, Christian, Klug, Lisa, Sorgo, Alice G., Eisenberg, Tobias, Büttner, Sabrina, Mariño, Guillermo, Koziel, Rafal, Jansen-Dürr, Pidder, Fröhlich, Kai-Uwe, Kroemer, Guido, Madeo, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006742/
https://www.ncbi.nlm.nih.gov/pubmed/24785424
http://dx.doi.org/10.1371/journal.pgen.1004347

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