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Effects of Oxidative Stress on the Solubility of HRD1, a Ubiquitin Ligase Implicated in Alzheimer’s Disease

The E3 ubiquitin ligase HRD1 is found in the endoplasmic reticulum membrane of brain neurons and is involved in endoplasmic reticulum-associated degradation. We previously demonstrated that suppression of HRD1 expression in neurons causes accumulation of amyloid precursor protein, resulting in amylo...

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Detalles Bibliográficos
Autores principales:	Saito, Ryo, Kaneko, Masayuki, Kitamura, Yoshihisa, Takata, Kazuyuki, Kawada, Koichi, Okuma, Yasunobu, Nomura, Yasuyuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006799/ https://www.ncbi.nlm.nih.gov/pubmed/24788773 http://dx.doi.org/10.1371/journal.pone.0094576

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