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Altered Regional and Circuit Resting-State Activity Associated with Unilateral Hearing Loss

The deprivation of sensory input after hearing damage results in functional reorganization of the brain including cross-modal plasticity in the sensory cortex and changes in cognitive processing. However, it remains unclear whether partial deprivation from unilateral auditory loss (UHL) would simila...

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Autores principales: Wang, Xingchao, Fan, Yang, Zhao, Fu, Wang, Zhenmin, Ge, Jianqiao, Zhang, Kai, Gao, Zhixian, Gao, Jia-Hong, Yang, Yihong, Fan, Jin, Zou, Qihong, Liu, Pinan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006821/
https://www.ncbi.nlm.nih.gov/pubmed/24788317
http://dx.doi.org/10.1371/journal.pone.0096126
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author Wang, Xingchao
Fan, Yang
Zhao, Fu
Wang, Zhenmin
Ge, Jianqiao
Zhang, Kai
Gao, Zhixian
Gao, Jia-Hong
Yang, Yihong
Fan, Jin
Zou, Qihong
Liu, Pinan
author_facet Wang, Xingchao
Fan, Yang
Zhao, Fu
Wang, Zhenmin
Ge, Jianqiao
Zhang, Kai
Gao, Zhixian
Gao, Jia-Hong
Yang, Yihong
Fan, Jin
Zou, Qihong
Liu, Pinan
author_sort Wang, Xingchao
collection PubMed
description The deprivation of sensory input after hearing damage results in functional reorganization of the brain including cross-modal plasticity in the sensory cortex and changes in cognitive processing. However, it remains unclear whether partial deprivation from unilateral auditory loss (UHL) would similarly affect the neural circuitry of cognitive processes in addition to the functional organization of sensory cortex. Here, we used resting-state functional magnetic resonance imaging to investigate intrinsic activity in 34 participants with UHL from acoustic neuroma in comparison with 22 matched normal controls. In sensory regions, we found decreased regional homogeneity (ReHo) in the bilateral calcarine cortices in UHL. However, there was an increase of ReHo in the right anterior insular cortex (rAI), the key node of cognitive control network (CCN) and multimodal sensory integration, as well as in the left parahippocampal cortex (lPHC), a key node in the default mode network (DMN). Moreover, seed-based resting–state functional connectivity analysis showed an enhanced relationship between rAI and several key regions of the DMN. Meanwhile, lPHC showed more negative relationship with components in the CCN and greater positive relationship in the DMN. Such reorganizations of functional connectivity within the DMN and between the DMN and CCN were confirmed by a graph theory analysis. These results suggest that unilateral sensory input damage not only alters the activity of the sensory areas but also reshapes the regional and circuit functional organization of the cognitive control network.
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spelling pubmed-40068212014-05-09 Altered Regional and Circuit Resting-State Activity Associated with Unilateral Hearing Loss Wang, Xingchao Fan, Yang Zhao, Fu Wang, Zhenmin Ge, Jianqiao Zhang, Kai Gao, Zhixian Gao, Jia-Hong Yang, Yihong Fan, Jin Zou, Qihong Liu, Pinan PLoS One Research Article The deprivation of sensory input after hearing damage results in functional reorganization of the brain including cross-modal plasticity in the sensory cortex and changes in cognitive processing. However, it remains unclear whether partial deprivation from unilateral auditory loss (UHL) would similarly affect the neural circuitry of cognitive processes in addition to the functional organization of sensory cortex. Here, we used resting-state functional magnetic resonance imaging to investigate intrinsic activity in 34 participants with UHL from acoustic neuroma in comparison with 22 matched normal controls. In sensory regions, we found decreased regional homogeneity (ReHo) in the bilateral calcarine cortices in UHL. However, there was an increase of ReHo in the right anterior insular cortex (rAI), the key node of cognitive control network (CCN) and multimodal sensory integration, as well as in the left parahippocampal cortex (lPHC), a key node in the default mode network (DMN). Moreover, seed-based resting–state functional connectivity analysis showed an enhanced relationship between rAI and several key regions of the DMN. Meanwhile, lPHC showed more negative relationship with components in the CCN and greater positive relationship in the DMN. Such reorganizations of functional connectivity within the DMN and between the DMN and CCN were confirmed by a graph theory analysis. These results suggest that unilateral sensory input damage not only alters the activity of the sensory areas but also reshapes the regional and circuit functional organization of the cognitive control network. Public Library of Science 2014-05-01 /pmc/articles/PMC4006821/ /pubmed/24788317 http://dx.doi.org/10.1371/journal.pone.0096126 Text en © 2014 Wang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Wang, Xingchao
Fan, Yang
Zhao, Fu
Wang, Zhenmin
Ge, Jianqiao
Zhang, Kai
Gao, Zhixian
Gao, Jia-Hong
Yang, Yihong
Fan, Jin
Zou, Qihong
Liu, Pinan
Altered Regional and Circuit Resting-State Activity Associated with Unilateral Hearing Loss
title Altered Regional and Circuit Resting-State Activity Associated with Unilateral Hearing Loss
title_full Altered Regional and Circuit Resting-State Activity Associated with Unilateral Hearing Loss
title_fullStr Altered Regional and Circuit Resting-State Activity Associated with Unilateral Hearing Loss
title_full_unstemmed Altered Regional and Circuit Resting-State Activity Associated with Unilateral Hearing Loss
title_short Altered Regional and Circuit Resting-State Activity Associated with Unilateral Hearing Loss
title_sort altered regional and circuit resting-state activity associated with unilateral hearing loss
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006821/
https://www.ncbi.nlm.nih.gov/pubmed/24788317
http://dx.doi.org/10.1371/journal.pone.0096126
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