Essential function for ErbB3 in breast cancer proliferation

The overexpression of the ErbB family of tyrosine kinase receptors is thought to be important in the development of many breast tumours. To date, most attention has focused on the ErbB2 receptor. Now, in a recent report, it has been shown that ErbB3 is a critical partner for the transforming activit...

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Detalles Bibliográficos
Autores principales: Perez-Nadales, Elena, Lloyd, Alison C
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC400683/
https://www.ncbi.nlm.nih.gov/pubmed/15084235
http://dx.doi.org/10.1186/bcr792
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author Perez-Nadales, Elena
Lloyd, Alison C
author_facet Perez-Nadales, Elena
Lloyd, Alison C
author_sort Perez-Nadales, Elena
collection PubMed
description The overexpression of the ErbB family of tyrosine kinase receptors is thought to be important in the development of many breast tumours. To date, most attention has focused on the ErbB2 receptor. Now, in a recent report, it has been shown that ErbB3 is a critical partner for the transforming activity of ErbB2 in breast cancer cells. Importantly, the proliferative signals from this transforming complex appear to act via the PI-3 kinase pathway.
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spelling pubmed-4006832004-05-01 Essential function for ErbB3 in breast cancer proliferation Perez-Nadales, Elena Lloyd, Alison C Breast Cancer Res Commentary The overexpression of the ErbB family of tyrosine kinase receptors is thought to be important in the development of many breast tumours. To date, most attention has focused on the ErbB2 receptor. Now, in a recent report, it has been shown that ErbB3 is a critical partner for the transforming activity of ErbB2 in breast cancer cells. Importantly, the proliferative signals from this transforming complex appear to act via the PI-3 kinase pathway. BioMed Central 2004 2004-04-02 /pmc/articles/PMC400683/ /pubmed/15084235 http://dx.doi.org/10.1186/bcr792 Text en Copyright © 2004 BioMed Central Ltd
spellingShingle Commentary
Perez-Nadales, Elena
Lloyd, Alison C
Essential function for ErbB3 in breast cancer proliferation
title Essential function for ErbB3 in breast cancer proliferation
title_full Essential function for ErbB3 in breast cancer proliferation
title_fullStr Essential function for ErbB3 in breast cancer proliferation
title_full_unstemmed Essential function for ErbB3 in breast cancer proliferation
title_short Essential function for ErbB3 in breast cancer proliferation
title_sort essential function for erbb3 in breast cancer proliferation
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC400683/
https://www.ncbi.nlm.nih.gov/pubmed/15084235
http://dx.doi.org/10.1186/bcr792
work_keys_str_mv AT pereznadaleselena essentialfunctionforerbb3inbreastcancerproliferation
AT lloydalisonc essentialfunctionforerbb3inbreastcancerproliferation

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